多能干细胞配子：未来不孕症治疗和生殖医学的缺口

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2025-04-05 DOI:10.1016/j.tice.2025.102904

Golnaz Shafiei , Sayyed Alireza Talaei , Seyed Ehsan Enderami , Mahmood Khaksary Mahabady , Javad Amini Mahabadi

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引用次数: 0

摘要

不育影响全世界10 - 15% %的育龄夫妇，男性不育与精子功能障碍有关，女性不育由排卵障碍和生殖异常引起。干细胞研究为通过生殖细胞分化治疗不孕症提供了一条有前途的途径。然而，在临床应用变得可行之前，标准化分化方案和确保体外配子的功能仍然是重大挑战。

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Pluripotent stem cell-derived gametes: A gap for infertility treatment and reproductive medicine in the future

Infertility affects 10–15 % of reproductive-age couples worldwide, with male infertility linked to sperm dysfunction and female infertility caused by ovulation disorders and reproductive abnormalities. Stem cell research presents a promising avenue for infertility treatment through germ cell differentiation. However, standardizing differentiation protocols and ensuring the functionality of in vitro-derived gametes remain significant challenges before clinical application becomes feasible.

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.