端肠草的镇痛作用、化学成分、毒理学及解毒研究进展

Ruoyue Huang , Cuishan Zhang , Yan Cheng , Binbin Zhang , Fei Li
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引用次数: 0

摘要

端长草是一种频率较高的常用中医术语,包括分布在中国各地的约40种药用植物。具有祛风、祛湿、消肿、止痛等药理作用。本研究旨在综述其镇痛和毒理学作用,包括临床不良反应、毒性化合物及其作用机制。方法从谷歌、谷歌Scholar、PubMed、Web of Science、中国知网(CNKI)、万方等学术数据库和搜索引擎中收集5种主要药用植物的相关镇痛毒理学报告。结果端肠草的临床副作用在国内已有大量研究记录。它们会对不同的器官产生副作用。据报道,至少有63种分离的化合物显示出毒性作用,主要是生物碱、黄酮、二萜和三萜。端长草的毒性机制与细胞凋亡、自噬、免疫损伤、氧化应激和代谢有关。使用新技术和适当的处理可以确保安全应用。一种典型的临床应用是作为镇痛药,有利于患者的身心健康,提高生活质量。端肠草,在中国使用了几个世纪的一系列药物,已被发现具有生物活性。为了在临床中合理使用端肠草作为镇痛药,暴露后毒性变化的途径和机制有待明确,预防措施有待进一步研究。此外,药物-药物相互作用在其应用过程中仍然是一个挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A review of potential analgesic effect, chemical components, toxicology and detoxification of Duanchangcao

A review of potential analgesic effect, chemical components, toxicology and detoxification of Duanchangcao

Introduction

Duanchangcao, a common term in traditional Chinese medicine with high frequency, including about 40 kinds of medicinal plants distributed all over China. They have the pharmacological effects, including dispelling wind, eliminating dampness, reducing oedema, and relieving pain.

Aim of the review

This study aims to review the analgesic and toxicological effects, including clinical adverse reactions, toxic chemical compounds and mechanisms.

Methods

The relevant analgesic and toxicological reports of five major medicinal plants were collected from various academic databases and search engines, including Google, Google Scholar, PubMed, Web of Science, CNKI and Wanfang.

Results

The clinical side effects of Duanchangcao have been recorded in numerous studies in China. They exhibit the side effects on different organs. At least 63 isolated chemical compounds have been reported to show toxic effects and mainly are alkaloids, flavones, diterpenes and triterpenes. The toxic mechanisms of Duanchangcao are associated with apoptosis, autophagy, immunological injury, oxidative stress and metabolism. The use of new technologies and proper processing can ensurre safe application. One typical clinical use has been developed as an analgesic drug, which benefits patients' physical and mental health, and improve the quality of life.

Discussion

Duanchangcao, a series of medicines used in China for several centuries, has been found to possess biological activities. To appropriately utilize Duanchangcao as an analgesic in clinical practice, the changed pathways and mechanisms of toxicity following the exposure need to be clarified, and the preventive approaches should be further studied. Additionally, drug-drug interaction still remain to be a challenge during their applications.
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