钯通过借氢策略催化芳香胺与二烯丙胺的n -单烯丙基化反应

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-04 DOI:10.1016/j.tet.2025.134648

Chengcheng Fang , Jie-Qing Ou , Xiaoye Mo , Yingqian Xu , Sifeng Li

引用次数: 0

摘要

建立了钯催化芳香胺与二烯丙胺在较低温度下的n -单烯丙基化反应，通过借氢策略合成n -单烯丙基化胺。以二烯丙胺为烯化剂，利用伯（杂）芳基胺、N-烷基仲（杂）芳基胺、N、N-二芳胺以及各种市售的含苯胺药物，可合成N-单烯丙基芳香胺，副产物为释放氨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-catalyzed chemoselective N-monoallylation of aromatic amines with diallylamine through a borrowing hydrogen strategy

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Palladium-catalyzed chemoselective N-monoallylation of aromatic amines with diallylamine through a borrowing hydrogen strategy

A palladium-catalyzed N-monoallylation reaction of aromatic amines with diallylamine at relatively low temperatures has been established for the synthesis of N-monoallylated amines via a borrowing hydrogen strategy. Employing diallylamine as the allylating agent, primary (hetero)aryl amines, N-alkyl secondary (hetero)aryl amines, N,N-diarylamines, and various commercially available aniline-containing pharmaceuticals can be utilized to synthesize N-monoallyl aromatic amines with releasing ammonia as the by-product.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.