放大神经元Ca2+，内质网梯子上的信号

IF 4.3 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2025-04-01 DOI:10.1016/j.ceca.2025.103016

Khaled Machaca

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引用次数: 0

摘要

树突Ca2+信号是神经传递和信号处理的关键，但详细的分子机制尚未阐明。Benedetti等人使用优雅和互补的成像方法发现树突中独特的内质网阶梯结构，并表明Ca2+信号蛋白在内质网(ER)-质膜（PM）连接处的精确定位支持Ca2+信号沿树突的整合。

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Scaling up neuronal Ca2+, signaling on ER ladders

Dendritic Ca²⁺ signaling is critical for neural transmission and signal processing, however the detailed molecular mechanisms have not been elucidated. Using elegant and complementary imaging approaches Benedetti et al. discover a distinctive ER ladder architecture in dendrites and show that precise localization of Ca²⁺ signaling proteins at endoplasmic reticulum (ER)-plasma membrane (PM) junctions supports integration of Ca²⁺ signaling along the dendrite.

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来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes