炎症和造血功能紊乱驱动小鼠VEXAS综合征模型的克隆优势

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2025-04-08 DOI:10.1038/s41591-025-03670-2

引用次数: 0

摘要

我们的研究表明，VEXAS 综合征小鼠模型的造血功能被具有炎症抗性的衰老型突变 HSPCs 所颠覆，这些 HSPCs 分化功能障碍，并通过其促炎性后代破坏造血功能。这种疾病机制解释了VEXAS综合征患者的克隆优势和骨髓衰竭（BMF），并可能具有转化意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Inflammation and disrupted hematopoiesis drive clonal dominance in a mouse model of VEXAS syndrome

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Inflammation and disrupted hematopoiesis drive clonal dominance in a mouse model of VEXAS syndrome

We show that hematopoiesis in a mouse model of VEXAS syndrome is subverted by inflammation-resilient, senescent-like mutant HSPCs, which have dysfunctional differentiation and undermine hematopoiesis through their proinflammatory progeny. This disease mechanism explains clonal dominance and bone marrow failure (BMF) in patients with VEXAS syndrome and could have translational implications.

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

期刊介绍： Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.