氧化还原化学传递系统:治疗神经退行性疾病的创新策略。

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI:10.1080/17425247.2025.2489558
Jeevan Lal Prajapati, Yogita Dhurandhar, As Pee Singh, Deepak Kumar Gupta, Vivek Singh Baghel, Umesh Kushwaha, Kamta Prasad Namdeo
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引用次数: 0

摘要

导读:由于寿命延长和人口结构的变化,预计影响中枢神经系统(CNS)疾病的患病率将显著上升。与年龄相关的脑功能衰退和神经元死亡是神经退行性疾病的特征,如帕金森病、阿尔茨海默病、亨廷顿病和肌萎缩侧索硬化症,这些疾病给治疗带来了巨大挑战。由于大多数治疗药物不能通过血脑屏障(BBB)到达大脑,尽管进行了大量的研究,但可供选择的治疗方法仍然很少。涵盖领域:本研究探讨了氧化还原化学传递系统在中枢神经系统药物传递中的作用,并解决了与神经退行性疾病(ND)相关的挑战。氧化还原化学传递系统提供了一种有前途的方法来加强利用氧化还原反应,促进治疗剂在血脑屏障上的运输。通过优化药物输送到大脑的途径,这项技术有可能大大改善ND的治疗。专家意见:随着我们对ND生物学基础理解的加深,有效干预措施的潜力也在增加。完善药物递送策略,如RCDS,是推进中枢神经系统治疗从研究到临床实践的关键。这些进步可能会改变ND的管理,改善治疗效果和患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases.

Introduction: It is anticipated that the prevalence of illnesses affecting the central nervous system (CNS) will rise significantly due to longer lifespans and changing demography. Age-related decline in brain function and neuronal death are features of neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis, which provide formidable treatment challenges. Because most therapeutic drugs cannot across the blood-brain barrier (BBB) to reach the brain, there are still few treatment alternatives available despite a great deal of research.

Areas covered: This study explores the role of redox chemical delivery systems in CNS drug delivery and addresses challenges associated with neurodegenerative disease (ND). Redox Chemical Delivery System offers a promising approach to enhancing leveraging redox reactions that facilitate the transport of therapeutic agents across the BBB. Through the optimization of medication delivery pathways to the brain, this technology has the potential to greatly improve the treatment of ND.

Expert opinion: As our understanding of the biological underpinnings of ND deepens, the potential for effective interventions increases. Refining drug delivery strategies, such as RCDS, is essential for advancing CNS therapies from research to clinical practice. These advancements could transform the management of ND, improving both treatment efficacy and patient outcomes.

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