由Ti-Zr-Cu-Pd-Sn金属玻璃和Fe-Mg合金组成的部分可降解复合材料，用于骨科应用。

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia Pub Date : 2025-04-04 DOI:10.1016/j.actbio.2025.04.011

Peng Du , Kun Zuo , Rongqiang Yan , Kun Li , Shilu Chen , Bo Yuan , Liang Zhang , Guoqiang Xie

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引用次数: 0

摘要

部分可降解生物材料是指可生物降解金属可逐渐被新生长的骨骼或活组织取代，并留下多孔惰性金属骨架与新骨组织稳定结合的智能植入物。在这项研究中，利用火花等离子烧结（SPS）技术，将钛锌铜钯锡金属玻璃（MG）与设计的铁镁合金整合在一起，设计出了一种部分可降解的复合材料。这种机械合金化技术成功地实现了不相溶的铁和镁的融合，解决了铁降解慢而镁分解快的问题，同时还最大限度地减少了金属框架因氢气演化而可能出现的断裂。受控的 Mg（Fe）降解促进了 Ca-P 化合物的形成，增强了铁镁复合材料的生物活性。这种设计使复合材料在压缩条件下具有塑性和韧性变形，为传统块状金属玻璃（BMG）常见的脆性断裂行为提供了可行的解决方案。这一进步有望与人体骨骼的自然生长速度保持一致，进一步增强 MG/Fe-Mg 复合材料的生物活性特性和实际应用。意义说明：在这项研究中，通过使用 SPS 将钛锌铜钯锡金属玻璃（MG）与设计的铁镁合金整合在一起，设计出了一种部分可降解的复合材料。Fe-Mg合金可作为临时的空间容纳物，逐渐被新形成的骨骼取代，从而在生物金属的生物降解和新骨骼的内向生长之间建立动态平衡。镁（铁）的降解促进了 Ca-P 化合物的形成，增强了复合材料的生物活性。这种设计赋予了复合材料在压缩下的塑性变形能力，为传统 MG 的脆性断裂行为提供了可行的解决方案。这一进步有望与人体骨骼的自然生长速度保持一致，从而进一步扩大 MG/Fe-Mg 复合材料的实际应用范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A partially degradable composite consisting of Ti-Zr-Cu-Pd-Sn metallic glass and Fe-Mg alloy for orthopedic applications

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A partially degradable composite consisting of Ti-Zr-Cu-Pd-Sn metallic glass and Fe-Mg alloy for orthopedic applications

Partially-degradable biomaterials refers to smart implants where biodegradable metals can gradually be replaced by newly growing bone or living tissues, and leave behind a porous inert metal skeleton that stably binds with the new bone tissue. In this research, a partially degradable composite was designed by integrating Ti-Zr-Cu-Pd-Sn metallic glass (MG) with designed Fe-Mg alloy using spark plasma sintering (SPS). The mechanical alloying technique successfully enabled the fusion of immiscible Fe and Mg, addressing the issues of Fe's slow degradation and Mg's rapid breakdown, while also minimizing potential fractures in the metal framework due to hydrogen gas evolution. The controlled degradation of Mg(Fe) promotes the formation of Ca-P compounds, enhancing the bioactivity of the Fe-Mg composite. This design endows the composite with plastic and ductile deformation under compression, providing a viable solution to the brittle fracture behaviour commonly associated with conventional bulk metallic glasses (BMGs). This advancement holds promise for aligning with the natural growth rate of human bone, further augmenting the bioactive properties and practical applications of the MG/Fe-Mg composite material.

Statement of significance

In this research, a partially degradable composite was designed by integrating Ti-Zr-Cu-Pd-Sn metallic glass (MG) with designed Fe-Mg alloy using SPS. The Fe-Mg alloy act as temporary space holders can gradually being replaced by newly formed bone, thus establishing a dynamic equilibrium between the biodegradation of the bio-metals and the inward growth of new bone. The degradation of Mg(Fe) promotes the formation of Ca-P compounds, enhancing the bioactivity of the composite. This design endows the composite with plastic deformation under compression, providing a viable solution to the brittle fracture behavior of conventional MGs. This advancement holds promise for aligning with the natural growth rate of human bone, further augmenting the practical applications of the MG/Fe-Mg composite.

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来源期刊

Acta Biomaterialia 工程技术-材料科学：生物材料

CiteScore

16.80

自引率

3.10%

发文量

776

审稿时长

30 days

期刊介绍： Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.