Sleep stage, sleep fragmentation and heart rate variability during the initial 3-h sleep period in patients with obstructive sleep apnea syndrome.

To investigate differences in polysomnography (PSG) parameters and heart rate variability (HRV) during the initial 3-h sleep period in patients with mild, moderate, and severe obstructive sleep apnea syndrome (OSA). According to the apnea-hypopnea index, patients were divided into 3 groups: mild, moderate, and severe (n = 23, 59, and 94, respectively). PSG was performed, and HRV (frequency domain analysis), sleep stage (S1, S2, S3, REM, and waking), and sleep fragmentation index (SFI) were measured during the initial 3-h sleep periods. The total S1 time was significantly longer in the severe group than in the mild and moderate groups (p < 0.001). The severe group had significantly shorter total S2 and S3 times than the mild (p = 0.014, p < 0.001) and moderate (p = 0.034, p = 0.029) groups did. The SFI was significantly greater in the severe group than in the mild and moderate groups (p < 0.001, p = 0.008). The high-frequency component (HF) of the HRV showed no significant differences except that it was significantly smaller during S3 in the moderate group than in the mild group (p = 0.026). Compared with those with mild/moderate status, patients with severe OSA have shallower sleep and a higher SFI, suggesting poorer sleep quality. Although HF during S3 was significantly smaller in the moderate group, it did not significantly differ between the mild and severe groups, suggesting that the parasympathetic nervous system might compensate for humoral and hypoxemic abnormalities in patients with severe OSA.