通过独特的里特式反应高效合成咪唑并[1,5-a]吡啶和苯并氮杂卓类似物的策略方法。

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Organic & Inorganic Au Pub Date : 2024-12-17 eCollection Date: 2025-04-02 DOI:10.1021/acsorginorgau.4c00075

Gunniga Tanomsiri, Suthimon Boonmee, Nattawadee Chaisan, Jumreang Tummatorn, Charnsak Thongsornkleeb, Somsak Ruchirawat

引用次数: 0

摘要

我们开发了通过ritter型反应合成咪唑[1,5-a]吡啶和苯氮平类似物的新方法。这些方法利用铋（III）三氟甲烷磺酸盐（Bi(OTf)3）与对甲苯磺酸（p-TsOH·H2O）结合，这是一种将苯基醇转化为苯基阳离子的有效催化剂。该程序提供了广泛的衬底范围，并提供所需的产品，产量范围从中等到优异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Strategic Methodologies for Efficient Synthesis of Imidazo[1,5-a]pyridine and Benzazepine Analogs via the Unique Ritter-Type Reaction.

We have developed novel approaches for synthesizing imidazo[1,5-a]pyridine and benzazepine analogs through a Ritter-type reaction. These methods utilize bismuth(III) trifluoromethanesulfonate (Bi(OTf)₃), an efficient catalyst for converting benzylic alcohol into benzylic cations, in combination with para-toluenesulfonic acid (p-TsOH·H₂O). The procedures offer a wide substrate scope and deliver the desired products in yields ranging from moderate to excellent.

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来源期刊

ACS Organic & Inorganic Au 有机化学、无机化学-

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.