Bette Loef, Esmee Bosma, Linda W M van Kerkhof, Karin I Proper, Debbie van Baarle, Martijn E T Dollé
{"title":"夜班工作与传染病易感性：系统回顾和荟萃分析。","authors":"Bette Loef, Esmee Bosma, Linda W M van Kerkhof, Karin I Proper, Debbie van Baarle, Martijn E T Dollé","doi":"10.5271/sjweh.4225","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>A growing body of research on infection susceptibility among night-shift workers has emerged, particularly since the COVID-19 pandemic. However, a comprehensive overview is still lacking. Therefore, this review aimed to synthesize the evidence on the association between night-shift work and susceptibility to infectious diseases.</p><p><strong>Methods: </strong>Embase and PsycINFO were systematically searched for studies published up to September 2024. Studies were included if they comprised a working population, night-shift workers were compared to non-shift workers, and the outcome was an infectious disease. Results were descriptively synthesized for common respiratory infections (flu and common cold), SARS-CoV-2 infection, and other infections. Pooled effect estimates were calculated using random-effects meta-analysis.</p><p><strong>Results: </strong>In total, 16 articles describing 14 studies among 191 320 workers were included. Based on 4 studies, night-shift work was not associated with a significantly increased risk of common respiratory infections [odds ratio (OR) 1.11, 95% confidence interval (CI) 0.97-1.27, I<sup>2</sup>=65.8%[. However, night-shift workers had a higher risk of SARS-CoV-2 infection than non-shift workers (OR 1.31, 95% CI 1.09-1.58, I<sup>2</sup>=92.2%, N=10 studies). This association was stronger in higher-quality studies and studies conducted in the first year of the COVID-19 pandemic. For other infections, insufficient studies were available to conduct a meta-analysis. The certainty of evidence was graded very low due to a limited number of (prospective cohort) studies and high inconsistency in the available studies.</p><p><strong>Conclusions: </strong>This systematic review and meta-analysis showed that night-shift work was associated with an increased risk of SARS-CoV-2 infection, but not of common respiratory infections. To address the lack of high-certainty evidence, more studies are needed that apply a prospective design with appropriate adjustment for confounding factors and more extensive information on night-shift work exposure.</p>","PeriodicalId":21528,"journal":{"name":"Scandinavian journal of work, environment & health","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Night-shift work and susceptibility to infectious diseases: a systematic review and meta-analysis.\",\"authors\":\"Bette Loef, Esmee Bosma, Linda W M van Kerkhof, Karin I Proper, Debbie van Baarle, Martijn E T Dollé\",\"doi\":\"10.5271/sjweh.4225\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>A growing body of research on infection susceptibility among night-shift workers has emerged, particularly since the COVID-19 pandemic. However, a comprehensive overview is still lacking. Therefore, this review aimed to synthesize the evidence on the association between night-shift work and susceptibility to infectious diseases.</p><p><strong>Methods: </strong>Embase and PsycINFO were systematically searched for studies published up to September 2024. Studies were included if they comprised a working population, night-shift workers were compared to non-shift workers, and the outcome was an infectious disease. Results were descriptively synthesized for common respiratory infections (flu and common cold), SARS-CoV-2 infection, and other infections. Pooled effect estimates were calculated using random-effects meta-analysis.</p><p><strong>Results: </strong>In total, 16 articles describing 14 studies among 191 320 workers were included. Based on 4 studies, night-shift work was not associated with a significantly increased risk of common respiratory infections [odds ratio (OR) 1.11, 95% confidence interval (CI) 0.97-1.27, I<sup>2</sup>=65.8%[. However, night-shift workers had a higher risk of SARS-CoV-2 infection than non-shift workers (OR 1.31, 95% CI 1.09-1.58, I<sup>2</sup>=92.2%, N=10 studies). This association was stronger in higher-quality studies and studies conducted in the first year of the COVID-19 pandemic. For other infections, insufficient studies were available to conduct a meta-analysis. The certainty of evidence was graded very low due to a limited number of (prospective cohort) studies and high inconsistency in the available studies.</p><p><strong>Conclusions: </strong>This systematic review and meta-analysis showed that night-shift work was associated with an increased risk of SARS-CoV-2 infection, but not of common respiratory infections. To address the lack of high-certainty evidence, more studies are needed that apply a prospective design with appropriate adjustment for confounding factors and more extensive information on night-shift work exposure.</p>\",\"PeriodicalId\":21528,\"journal\":{\"name\":\"Scandinavian journal of work, environment & health\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scandinavian journal of work, environment & health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5271/sjweh.4225\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian journal of work, environment & health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5271/sjweh.4225","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Night-shift work and susceptibility to infectious diseases: a systematic review and meta-analysis.
Objectives: A growing body of research on infection susceptibility among night-shift workers has emerged, particularly since the COVID-19 pandemic. However, a comprehensive overview is still lacking. Therefore, this review aimed to synthesize the evidence on the association between night-shift work and susceptibility to infectious diseases.
Methods: Embase and PsycINFO were systematically searched for studies published up to September 2024. Studies were included if they comprised a working population, night-shift workers were compared to non-shift workers, and the outcome was an infectious disease. Results were descriptively synthesized for common respiratory infections (flu and common cold), SARS-CoV-2 infection, and other infections. Pooled effect estimates were calculated using random-effects meta-analysis.
Results: In total, 16 articles describing 14 studies among 191 320 workers were included. Based on 4 studies, night-shift work was not associated with a significantly increased risk of common respiratory infections [odds ratio (OR) 1.11, 95% confidence interval (CI) 0.97-1.27, I2=65.8%[. However, night-shift workers had a higher risk of SARS-CoV-2 infection than non-shift workers (OR 1.31, 95% CI 1.09-1.58, I2=92.2%, N=10 studies). This association was stronger in higher-quality studies and studies conducted in the first year of the COVID-19 pandemic. For other infections, insufficient studies were available to conduct a meta-analysis. The certainty of evidence was graded very low due to a limited number of (prospective cohort) studies and high inconsistency in the available studies.
Conclusions: This systematic review and meta-analysis showed that night-shift work was associated with an increased risk of SARS-CoV-2 infection, but not of common respiratory infections. To address the lack of high-certainty evidence, more studies are needed that apply a prospective design with appropriate adjustment for confounding factors and more extensive information on night-shift work exposure.
期刊介绍：
The aim of the Journal is to promote research in the fields of occupational and environmental health and safety and to increase knowledge through the publication of original research articles, systematic reviews, and other information of high interest. Areas of interest include occupational and environmental epidemiology, occupational and environmental medicine, psychosocial factors at work, physical work load, physical activity work-related mental and musculoskeletal problems, aging, work ability and return to work, working hours and health, occupational hygiene and toxicology, work safety and injury epidemiology as well as occupational health services. In addition to observational studies, quasi-experimental and intervention studies are welcome as well as methodological papers, occupational cohort profiles, and studies associated with economic evaluation. The Journal also publishes short communications, case reports, commentaries, discussion papers, clinical questions, consensus reports, meeting reports, other reports, book reviews, news, and announcements (jobs, courses, events etc).
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