儿科患者血清中维生素 D 水平与幽门螺旋杆菌感染的关系。

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI:10.5114/pg.2024.146213
Kairat Rysbekov, Sagira Abdrakhmanova, Rashida Satybaeva, Dmitry Babenko, Zhanat Abdikadyr
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引用次数: 0

摘要

简介:幽门螺杆菌是一种全球流行的感染,特别是在发展中国家,对儿童胃肠道健康有重大影响。最近的研究表明,维生素D及其代谢物通过其杀菌特性增强幽门螺杆菌根除治疗的有效性之间存在潜在联系。目的:探讨儿童幽门螺旋杆菌检测患者维生素D水平与临床管理及治疗效果的关系。材料和方法:本研究对128名儿科患者进行队列研究。根据幽门螺旋杆菌检测阳性(第一组- A)或阴性(第二组- B),将患者分为两组。为了确定维生素D的水平,两组的所有参与者都采集了静脉血。1组为指标达10 ng/ml的患者;2组为指标在10 ~ 20 ng/ml之间的患者;组3水平为20 ~ 30 ng/ml;4组指标均大于30 ng/ml。评估了这些组参与者幽门螺杆菌根除方案的效率。结果:A组的平均值高于B组,分别为17.1和14.9,p值为0.03。在维生素D水平低于30 ng/ml的参与者中,幽门螺杆菌患病率较高。研究结果表明,血清中维生素D水平低于30纳克/毫升可能是儿童幽门螺杆菌传播的一个易感因素。同时,低于30 ng/ml的不同水平的缺乏对幽门螺杆菌感染的频率没有影响。结论:获得的数据可用于制定主要诊断为幽门螺杆菌并需要根除治疗的儿童患者的临床管理指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Connection of vitamin D levels in blood serum with Helicobacter pylori infection in paediatric patients.

Introduction: Helicobacter pylori is a globally prevalent infection, particularly in developing countries, with significant implications for gastrointestinal health in children. Recent studies suggest a potential link between vitamin D and its metabolites in enhancing the effectiveness of H. pylori eradication therapies through their bactericidal properties.

Aim: To investigate the correlation between the vitamin D levels and their influence on clinical management and treatment results of children patients, tested for H. pylori.

Material and methods: The study was conducted on a cohort of 128 paediatric patients. They were divided into 2 groups, depending on whether positive (first group - A) or negative (second group - B) for H. pylori. To determine vitamin D levels, venous blood was taken from all participants from both groups. Group 1 included patients whose indexes were up to 10 ng/ml; Group 2 included patients whose indexes were from 10 ng/ml to 20 ng/ml; Group 3 levels were from 20 ng/ml to 30 ng/ml; and Group 4 indexes were over 30 ng/ml. The efficiency of the H. pylori eradication scheme in participants of these groups was evaluated.

Results: The mean values in Group A were higher than those in Group B: 17.1 and 14.9, respectively, p-value 0.03. Helicobacter pylori prevalence was higher in participants with vitamin D levels below 30 ng/ml. As a result of the study, it was established that vitamin D levels below 30 ng/ml in blood serum could be a predisposing factor in the spread of H. pylori in paediatric patients. At the same time, different levels of deficiency below 30 ng/ml did not affect the frequency of H. pylori infection.

Conclusions: The obtained data can be used in developing guidelines for clinical management of children patients who are primarily diagnosed with H. pylori and require eradication therapy.

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来源期刊
Przegla̜d Gastroenterologiczny
Przegla̜d Gastroenterologiczny GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.20
自引率
7.70%
发文量
50
审稿时长
6-12 weeks
期刊介绍: Gastroenterology Review is a journal published each 2 months, aimed at gastroenterologists and general practitioners. Published under the patronage of Consultant in Gastroenterology and Polish Pancreatic Club.
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