{"title":"身体成分测量对年轻成年黑人和白人女性左心室质量指数升高的贡献。","authors":"Jordan Sill, Jessica G Woo, Elaine M Urbina","doi":"10.1155/ijhy/8274623","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objective:</b> We aimed to determine the contribution of various types of body composition measures to the increased left ventricular mass index (LVMI) in young adult females. <b>Methods:</b> Data from the National Growth and Health Study (NGHS), including dual-energy x-ray absorptiometry (DEXA), magnetic resonance imaging (MRI), and echocardiogram, were analyzed (<i>N</i> = 589, 54.8% Black, mean age: 24.9 ± 0.7 years). Logistic and linear regressions were conducted to assess for the contribution of fat mass (FM) and fat-free mass (FFM) by DEXA and subcutaneous abdominal adipose tissue (SAT) mass and visceral adipose tissue (VAT) volume by MRI in relation to the increased LVMI or left ventricular hypertrophy (LVH; LVMI ≥ 38.6 g/m<sup>2.7</sup>). <b>Results:</b> FM (<i>β</i> ± SE: 0.025 ± 0.002, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.313), FFM (0.059 ± 0.003, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.374), SAT (0.054 ± 0.005, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.291), and VAT (0.194 ± 0.019, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.256) were each significantly associated with the increased LVMI, with FFM having the greatest association. Black race was associated with the increased LVMI in models involving individual fat mass types (0.055 ± 0.020, <i>p</i> < 0.01 for FM; 0.054 ± 0.021, <i>p</i> = 0.01 for SAT; 0.119 ± 0.021, <i>p</i> < 0.01 for VAT). In logistic models considering all mass types, FFM (OR [95% CI]: 1.62 [1.46-1.79], <i>p</i> < 0.01) and systolic blood pressure (SBP) (1.04 [1.01-1.07], <i>p</i> < 0.01) were significant contributors to LVH (area under the receiver-operator characteristic curve 0.847), and only FFM was a significant contributor in the corresponding linear regression (<i>β</i> ± SE: 0.059 ± 0.003, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.374). <b>Conclusions:</b> FFM had the greatest association with LVH and LVMI, confirming previously published data. Through the use of MRI, we found that neither subtype of abdominal fat mass (SAT and VAT) better explained the variance in LVMI than FFM.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"8274623"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972137/pdf/","citationCount":"0","resultStr":"{\"title\":\"Contribution of Body Composition Measures to the Increased Left Ventricular Mass Index in Young Adult Black and White Females.\",\"authors\":\"Jordan Sill, Jessica G Woo, Elaine M Urbina\",\"doi\":\"10.1155/ijhy/8274623\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objective:</b> We aimed to determine the contribution of various types of body composition measures to the increased left ventricular mass index (LVMI) in young adult females. <b>Methods:</b> Data from the National Growth and Health Study (NGHS), including dual-energy x-ray absorptiometry (DEXA), magnetic resonance imaging (MRI), and echocardiogram, were analyzed (<i>N</i> = 589, 54.8% Black, mean age: 24.9 ± 0.7 years). Logistic and linear regressions were conducted to assess for the contribution of fat mass (FM) and fat-free mass (FFM) by DEXA and subcutaneous abdominal adipose tissue (SAT) mass and visceral adipose tissue (VAT) volume by MRI in relation to the increased LVMI or left ventricular hypertrophy (LVH; LVMI ≥ 38.6 g/m<sup>2.7</sup>). <b>Results:</b> FM (<i>β</i> ± SE: 0.025 ± 0.002, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.313), FFM (0.059 ± 0.003, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.374), SAT (0.054 ± 0.005, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.291), and VAT (0.194 ± 0.019, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.256) were each significantly associated with the increased LVMI, with FFM having the greatest association. Black race was associated with the increased LVMI in models involving individual fat mass types (0.055 ± 0.020, <i>p</i> < 0.01 for FM; 0.054 ± 0.021, <i>p</i> = 0.01 for SAT; 0.119 ± 0.021, <i>p</i> < 0.01 for VAT). In logistic models considering all mass types, FFM (OR [95% CI]: 1.62 [1.46-1.79], <i>p</i> < 0.01) and systolic blood pressure (SBP) (1.04 [1.01-1.07], <i>p</i> < 0.01) were significant contributors to LVH (area under the receiver-operator characteristic curve 0.847), and only FFM was a significant contributor in the corresponding linear regression (<i>β</i> ± SE: 0.059 ± 0.003, <i>p</i> < 0.01, adjusted <i>R</i> <sup>2</sup> = 0.374). <b>Conclusions:</b> FFM had the greatest association with LVH and LVMI, confirming previously published data. Through the use of MRI, we found that neither subtype of abdominal fat mass (SAT and VAT) better explained the variance in LVMI than FFM.</p>\",\"PeriodicalId\":14132,\"journal\":{\"name\":\"International Journal of Hypertension\",\"volume\":\"2025 \",\"pages\":\"8274623\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-03-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972137/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Hypertension\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/ijhy/8274623\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Hypertension","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/ijhy/8274623","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
摘要
目的:我们旨在确定各种身体成分测量对年轻成年女性左心室质量指数(LVMI)升高的贡献。方法:分析来自国家生长与健康研究(NGHS)的数据,包括双能x线吸收仪(DEXA)、磁共振成像(MRI)和超声心动图(N = 589,黑人54.8%,平均年龄:24.9±0.7岁)。采用Logistic回归和线性回归评估DEXA测量的脂肪量(FM)和无脂量(FFM)以及MRI测量的皮下脂肪组织(SAT)质量和内脏脂肪组织(VAT)体积与左心室肥厚(LVH)或左心室心肌梗死(LVMI)增加的关系;LVMI≥38.6 g/m2.7)。结果:FM (β±SE: 0.025±0.002,p R 2 = 0.313)、FFM(0.059±0.003,p R 2 = 0.374)、SAT(0.054±0.005,p R 2 = 0.291)、VAT(0.194±0.019,p R 2 = 0.256)与LVMI升高均有显著相关性,其中FFM相关性最大。在涉及个体脂肪量类型的模型中,黑人种族与LVMI增加相关(0.055±0.020,p = 0.01);0.119±0.021,p p pβ±SE: 0.059±0.003,p R 2 = 0.374)。结论:FFM与LVH和LVMI的相关性最大,证实了先前发表的数据。通过使用MRI,我们发现腹部脂肪块亚型(SAT和VAT)都不能比FFM更好地解释LVMI的差异。
Contribution of Body Composition Measures to the Increased Left Ventricular Mass Index in Young Adult Black and White Females.
Objective: We aimed to determine the contribution of various types of body composition measures to the increased left ventricular mass index (LVMI) in young adult females. Methods: Data from the National Growth and Health Study (NGHS), including dual-energy x-ray absorptiometry (DEXA), magnetic resonance imaging (MRI), and echocardiogram, were analyzed (N = 589, 54.8% Black, mean age: 24.9 ± 0.7 years). Logistic and linear regressions were conducted to assess for the contribution of fat mass (FM) and fat-free mass (FFM) by DEXA and subcutaneous abdominal adipose tissue (SAT) mass and visceral adipose tissue (VAT) volume by MRI in relation to the increased LVMI or left ventricular hypertrophy (LVH; LVMI ≥ 38.6 g/m2.7). Results: FM (β ± SE: 0.025 ± 0.002, p < 0.01, adjusted R2 = 0.313), FFM (0.059 ± 0.003, p < 0.01, adjusted R2 = 0.374), SAT (0.054 ± 0.005, p < 0.01, adjusted R2 = 0.291), and VAT (0.194 ± 0.019, p < 0.01, adjusted R2 = 0.256) were each significantly associated with the increased LVMI, with FFM having the greatest association. Black race was associated with the increased LVMI in models involving individual fat mass types (0.055 ± 0.020, p < 0.01 for FM; 0.054 ± 0.021, p = 0.01 for SAT; 0.119 ± 0.021, p < 0.01 for VAT). In logistic models considering all mass types, FFM (OR [95% CI]: 1.62 [1.46-1.79], p < 0.01) and systolic blood pressure (SBP) (1.04 [1.01-1.07], p < 0.01) were significant contributors to LVH (area under the receiver-operator characteristic curve 0.847), and only FFM was a significant contributor in the corresponding linear regression (β ± SE: 0.059 ± 0.003, p < 0.01, adjusted R2 = 0.374). Conclusions: FFM had the greatest association with LVH and LVMI, confirming previously published data. Through the use of MRI, we found that neither subtype of abdominal fat mass (SAT and VAT) better explained the variance in LVMI than FFM.
期刊介绍:
International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.