Maram Aldarsooni, Mohammad Alfarah, Fatimah Albohammod, Dania Al-Jaroudi
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引用次数: 0
摘要
背景：在卵巢刺激周期中，黄体生成素（LH）过早激增12 - 25%已被普遍报道。然而，关于过早黄体生成素激增是否影响妊娠结局，目前仍缺乏共识。目的：本研究旨在评估在沙特阿拉伯利雅得的一家三级医院，在卵胞浆内单精子注射或体外受精周期刺激期间，有和没有过早黄体生成素激增的妇女妊娠率的影响。材料与方法：采用横断面研究。回顾了2022年1月至2022年12月期间接受IVF/ICSI周期的771名妇女的相关信息。根据黄体生成素过早增高分为两组。结果：两组患者的特征无显著性差异。未发生黄体生成素过早增高的妇女的活产率明显高于发生黄体生成素过早增高的妇女（12.9% vs. 5.6%） （p = 0.010）。在收集的卵母细胞数量、M2和受精率方面，未出现过早LH激增的女性明显更高，p值分别为0.001、0.002和0.004。结论：该研究表明，没有过早黄体生成素激增的妇女的活产率明显更高。
Effect of premature luteinizing hormone surge on pregnancy outcomes in intracytoplasmic sperm injection or in vitro fertilization cycles.
Background: A premature surge in luteinizing hormone (LH) during ovarian stimulation cycles between 12 and 25% has been commonly reported. However, there is still a lack of consensus on whether premature LH surge affects pregnancy outcomes.
Objective: This study aimed to evaluate the effect of premature LH surge on pregnancy rates in women with and without premature LH surge during intracytoplasmic sperm injection or stimulation of in vitro fertilization cycles at a tertiary hospital in Riyadh, Saudi Arabia.
Materials and methods: A cross-sectional study was conducted. Information related to 771 women who had IVF/ICSI cycles between January 2022 and December 2022 was reviewed. Patients were divided into two groups based on premature LH surge.
Results: There was no significant difference in patients' characteristics. The live birth rates were significantly higher in women without premature LH surge than in women with LH surge (12.9% vs. 5.6%) (p = 0.010). With regard to the number of oocytes collected, M2, and fertilization rate, these were significantly higher in women without premature LH surge, with p-values of 0.001, 0.002, and 0.004, respectively.
Conclusion: The study demonstrates significantly higher live birth rates in women without premature LH surge.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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