Dan Wu, Changlei Han, Suting Xiong, Peipei Zhang, Han Gao, Jingyi Jiang, Fengming Wang, Xufeng Lv, Fang Yao, Qinwen Xu
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Prevention of varicella-zoster virus infection in early childhood children: effect of 1 versus 2 doses of varicella vaccine on antibody levels.
Objective: This study aimed to ascertain the factors influencing the varicella-zoster virus (VZV) IgG seropositivity and to evaluate the efficacy of varicella vaccination with 1- and 2-dose schedules.
Methods: A systematic sampling method was employed to recruit subjects. VZV IgG was calculated using the geometric mean concentration (GMC) and a 95% confidence interval (CI). A multifactorial logistic regression model was employed to calculate the odds ratios (OR) and to identify the influential factors for varicella antibody positivity. A generalized additive model for location, shape and scale (GAMLSS) was employed to compare centile reference values and centile curves of antibody levels for different doses of varicella vaccine (VarV).
Results: 785 individuals were included. The VarV positivity rate was 57.7% for 1 dose and 84.2% for 2 doses. Varicella antibody positivity was significantly associated with VarV doses and time since last vaccination. The GAMLSS model indicated a decline in VZV IgG over time, with the 2-dose group demonstrating superior performance to the 1-dose group across all centile reference values and curves.
Conclusion: A 2-dose schedule is more effective in improving both VZV IgG seropositivity and GMC than a single dose. The inclusion of the VarV in routine immunization programme should be considered.
期刊介绍：
Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings.
The journal covers a wide range of topics, including:
Etiology: The study of the causes of infectious diseases.
Pathogenesis: The process by which an infectious agent causes disease.
Diagnosis: The methods and techniques used to identify infectious diseases.
Treatment: The medical interventions and strategies employed to treat infectious diseases.
Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies.
Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections.
In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.
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