Junwei Li, Qingqing Yang, Min Zhang, Jie Yao, Bolun Liu, Yichao Luan, Yunlin Chen, Chaohua Fang, Cheng-Kung Cheng
{"title":"胫骨内侧楔形高位截骨后胫骨后斜度的影响因素。","authors":"Junwei Li, Qingqing Yang, Min Zhang, Jie Yao, Bolun Liu, Yichao Luan, Yunlin Chen, Chaohua Fang, Cheng-Kung Cheng","doi":"10.3389/fbioe.2025.1525542","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Medial Opening-wedge High Tibial Osteotomy (HTO) is an effective treatment for medial compartment osteoarthritis and knee varus in relatively young and active patients. While it can effectively correct lower limb alignment in the coronal plane, it may also affect the posterior tibial slope (PTS) in the sagittal plane. However, the factors influencing PTS and methods for maintaining PTS stability remain controversial.</p><p><strong>Methods: </strong>A lower limb geometric model was constructed based on the CT data from a patient with medial knee osteoarthritis and varus knee. Multiple models were developed to simulate various conditions: seven different medial cortex inclinations of the proximal tibia (-15°-15°), seven coronal plane inclinations of the central osteotomy plane (-15°-15°), seven sagittal plane inclinations of the hinge axis (-15°-15°), seven hinge axis heights (-7 mm-7 mm), and seven hinge axis inclinations in the axial plane (-15°-15°). Changes in the ratio between anterior and posterior opening gap (RAPOG) and PTS were analyzed.</p><p><strong>Results: </strong>The medial cortex inclination of the proximal tibia, coronal plane inclination of the central osteotomy plane, inclination of the sagittal plane of the hinge axis, and height of the hinge axis did not alter the PTS; however, these factors did affect RAPOG, with increased values leading to decrease in RAPOG. The ranges of RAPOG for these factors were 76.37%-54.83%, 68.91%-60.94%, 68.04%-64.08%, and 70.38%-62.61%, respectively. However, the hinge axis inclination on the axial plane affects PTS, for inclinations of -15°, -10°, -5°, 0°, 5°, 10°, and 15°, the PTS decreased 2.48°, 1.83°, 0.98°, 0°, -0.97°, -1.82°, and -2.53°, respectively. To maintain a constant PTS, RAPOG should be readjusted to 65.13%, 66.01%, 66.27%, 65.76%, 65.03%, 65.15%, and 65.57%, respectively.</p><p><strong>Discussion: </strong>The inclination of the hinge axis in the axial plane affects PTS, as its value increases, PTS also increases. To maintain a constant PTS, RAPOG should be readjusted. Understanding these relationships is essential for optimizing surgical techniques to minimize unintended changes in PTS.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1525542"},"PeriodicalIF":4.3000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968708/pdf/","citationCount":"0","resultStr":"{\"title\":\"Factors influencing the posterior tibial slope after medial opening-wedge high tibial osteotomy.\",\"authors\":\"Junwei Li, Qingqing Yang, Min Zhang, Jie Yao, Bolun Liu, Yichao Luan, Yunlin Chen, Chaohua Fang, Cheng-Kung Cheng\",\"doi\":\"10.3389/fbioe.2025.1525542\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Medial Opening-wedge High Tibial Osteotomy (HTO) is an effective treatment for medial compartment osteoarthritis and knee varus in relatively young and active patients. While it can effectively correct lower limb alignment in the coronal plane, it may also affect the posterior tibial slope (PTS) in the sagittal plane. However, the factors influencing PTS and methods for maintaining PTS stability remain controversial.</p><p><strong>Methods: </strong>A lower limb geometric model was constructed based on the CT data from a patient with medial knee osteoarthritis and varus knee. Multiple models were developed to simulate various conditions: seven different medial cortex inclinations of the proximal tibia (-15°-15°), seven coronal plane inclinations of the central osteotomy plane (-15°-15°), seven sagittal plane inclinations of the hinge axis (-15°-15°), seven hinge axis heights (-7 mm-7 mm), and seven hinge axis inclinations in the axial plane (-15°-15°). Changes in the ratio between anterior and posterior opening gap (RAPOG) and PTS were analyzed.</p><p><strong>Results: </strong>The medial cortex inclination of the proximal tibia, coronal plane inclination of the central osteotomy plane, inclination of the sagittal plane of the hinge axis, and height of the hinge axis did not alter the PTS; however, these factors did affect RAPOG, with increased values leading to decrease in RAPOG. The ranges of RAPOG for these factors were 76.37%-54.83%, 68.91%-60.94%, 68.04%-64.08%, and 70.38%-62.61%, respectively. However, the hinge axis inclination on the axial plane affects PTS, for inclinations of -15°, -10°, -5°, 0°, 5°, 10°, and 15°, the PTS decreased 2.48°, 1.83°, 0.98°, 0°, -0.97°, -1.82°, and -2.53°, respectively. To maintain a constant PTS, RAPOG should be readjusted to 65.13%, 66.01%, 66.27%, 65.76%, 65.03%, 65.15%, and 65.57%, respectively.</p><p><strong>Discussion: </strong>The inclination of the hinge axis in the axial plane affects PTS, as its value increases, PTS also increases. To maintain a constant PTS, RAPOG should be readjusted. 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Factors influencing the posterior tibial slope after medial opening-wedge high tibial osteotomy.
Introduction: Medial Opening-wedge High Tibial Osteotomy (HTO) is an effective treatment for medial compartment osteoarthritis and knee varus in relatively young and active patients. While it can effectively correct lower limb alignment in the coronal plane, it may also affect the posterior tibial slope (PTS) in the sagittal plane. However, the factors influencing PTS and methods for maintaining PTS stability remain controversial.
Methods: A lower limb geometric model was constructed based on the CT data from a patient with medial knee osteoarthritis and varus knee. Multiple models were developed to simulate various conditions: seven different medial cortex inclinations of the proximal tibia (-15°-15°), seven coronal plane inclinations of the central osteotomy plane (-15°-15°), seven sagittal plane inclinations of the hinge axis (-15°-15°), seven hinge axis heights (-7 mm-7 mm), and seven hinge axis inclinations in the axial plane (-15°-15°). Changes in the ratio between anterior and posterior opening gap (RAPOG) and PTS were analyzed.
Results: The medial cortex inclination of the proximal tibia, coronal plane inclination of the central osteotomy plane, inclination of the sagittal plane of the hinge axis, and height of the hinge axis did not alter the PTS; however, these factors did affect RAPOG, with increased values leading to decrease in RAPOG. The ranges of RAPOG for these factors were 76.37%-54.83%, 68.91%-60.94%, 68.04%-64.08%, and 70.38%-62.61%, respectively. However, the hinge axis inclination on the axial plane affects PTS, for inclinations of -15°, -10°, -5°, 0°, 5°, 10°, and 15°, the PTS decreased 2.48°, 1.83°, 0.98°, 0°, -0.97°, -1.82°, and -2.53°, respectively. To maintain a constant PTS, RAPOG should be readjusted to 65.13%, 66.01%, 66.27%, 65.76%, 65.03%, 65.15%, and 65.57%, respectively.
Discussion: The inclination of the hinge axis in the axial plane affects PTS, as its value increases, PTS also increases. To maintain a constant PTS, RAPOG should be readjusted. Understanding these relationships is essential for optimizing surgical techniques to minimize unintended changes in PTS.
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.