Nur Batrisyia Azlan, Siti Sarah Mohamad Zaid, Siti Rosmani Md Zin
{"title":"Toxicity effects of cadmium exposure on early development: a review of current evidence.","authors":"Nur Batrisyia Azlan, Siti Sarah Mohamad Zaid, Siti Rosmani Md Zin","doi":"10.1080/10408444.2025.2462653","DOIUrl":null,"url":null,"abstract":"<p><p>In recent decades, cadmium (Cd) has garnered significant global attention due to its extensive and potentially harmful health effects, even at low exposure levels. Improper management of cadmium waste can lead to severe environmental pollution, ultimately affecting living organisms through various exposure routes. This study aims to compile and review the latest data on the toxic effects of Cd exposure on critical body systems and functions, with a particular focus on the early stages of development (prepubertal period) across different species. The review highlights Cd's impact on the reproductive, neurobehavioral, cognitive, immune, renal systems, gastrointestinal, and endocrine systems. Additionally, it provides valuable insights into how early Cd exposure may contribute to the development of various diseases in later life.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"1-20"},"PeriodicalIF":5.7000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10408444.2025.2462653","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Toxicity effects of cadmium exposure on early development: a review of current evidence.
In recent decades, cadmium (Cd) has garnered significant global attention due to its extensive and potentially harmful health effects, even at low exposure levels. Improper management of cadmium waste can lead to severe environmental pollution, ultimately affecting living organisms through various exposure routes. This study aims to compile and review the latest data on the toxic effects of Cd exposure on critical body systems and functions, with a particular focus on the early stages of development (prepubertal period) across different species. The review highlights Cd's impact on the reproductive, neurobehavioral, cognitive, immune, renal systems, gastrointestinal, and endocrine systems. Additionally, it provides valuable insights into how early Cd exposure may contribute to the development of various diseases in later life.
期刊介绍:
Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.