5-羟色胺及其代谢物5-羟吲哚乙酸在大鼠大脑中的变化。

IF 1.3 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedical Research-tokyo Pub Date : 2025-01-01 DOI:10.2220/biomedres.46.77

Sachiko Hiraide, Takuji Machida, Mina Yamada, Honoka Furukawa, Takahiro Yamamoto, Naoya Hamaue, Kenji Iizuka

{"title":"5-羟色胺及其代谢物5-羟吲哚乙酸在大鼠大脑中的变化。","authors":"Sachiko Hiraide, Takuji Machida, Mina Yamada, Honoka Furukawa, Takahiro Yamamoto, Naoya Hamaue, Kenji Iizuka","doi":"10.2220/biomedres.46.77","DOIUrl":null,"url":null,"abstract":"During the delayed emesis phase, methotrexate tended to increase 5-hydroxytryptamine (5-HT) levels in midbrain and significantly increased 5-hydroxyindole-acetic acid (5-HIAA), a metabolite of 5-HT, levels in the area postrema and in the cerebral cortex in rats. However, methotrexate did not increase mRNA expression of 5-HT biosynthesis/metabolism enzyme in the area postrema. The increased 5-HIAA levels in the area postrema may result from enhanced intestinal 5-HT synthesis, with 5-HIAA reaching the area postrema via circulation. Additionally, the rise in cortical 5-HIAA levels might reflect stress-related increases in brain tryptophan influx.","PeriodicalId":9138,"journal":{"name":"Biomedical Research-tokyo","volume":"46 2","pages":"77-81"},"PeriodicalIF":1.3000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Changes in 5-hydroxytryptamine and its metabolite, 5-hydroxyindole-acetic acid, levels in the brain of rats administered with methotrexate.\",\"authors\":\"Sachiko Hiraide, Takuji Machida, Mina Yamada, Honoka Furukawa, Takahiro Yamamoto, Naoya Hamaue, Kenji Iizuka\",\"doi\":\"10.2220/biomedres.46.77\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"During the delayed emesis phase, methotrexate tended to increase 5-hydroxytryptamine (5-HT) levels in midbrain and significantly increased 5-hydroxyindole-acetic acid (5-HIAA), a metabolite of 5-HT, levels in the area postrema and in the cerebral cortex in rats. However, methotrexate did not increase mRNA expression of 5-HT biosynthesis/metabolism enzyme in the area postrema. The increased 5-HIAA levels in the area postrema may result from enhanced intestinal 5-HT synthesis, with 5-HIAA reaching the area postrema via circulation. Additionally, the rise in cortical 5-HIAA levels might reflect stress-related increases in brain tryptophan influx.\",\"PeriodicalId\":9138,\"journal\":{\"name\":\"Biomedical Research-tokyo\",\"volume\":\"46 2\",\"pages\":\"77-81\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Research-tokyo\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2220/biomedres.46.77\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Research-tokyo","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2220/biomedres.46.77","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

在大鼠迟发性呕吐阶段，甲氨蝶呤往往会增加中脑的 5-羟色胺（5-HT）水平，并显著增加后脑区和大脑皮层的 5-羟基吲哚乙酸（5-HIAA）（5-HT 的一种代谢产物）水平。然而，甲氨蝶呤不会增加后脑区 5-HT 生物合成/代谢酶的 mRNA 表达。脑后区 5-HIAA 水平的增加可能是由于肠道 5-HT 合成增强，5-HIAA 通过血液循环到达脑后区。此外，大脑皮层 5-HIAA 水平的升高可能反映了与压力有关的大脑色氨酸流入量的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Changes in 5-hydroxytryptamine and its metabolite, 5-hydroxyindole-acetic acid, levels in the brain of rats administered with methotrexate.

During the delayed emesis phase, methotrexate tended to increase 5-hydroxytryptamine (5-HT) levels in midbrain and significantly increased 5-hydroxyindole-acetic acid (5-HIAA), a metabolite of 5-HT, levels in the area postrema and in the cerebral cortex in rats. However, methotrexate did not increase mRNA expression of 5-HT biosynthesis/metabolism enzyme in the area postrema. The increased 5-HIAA levels in the area postrema may result from enhanced intestinal 5-HT synthesis, with 5-HIAA reaching the area postrema via circulation. Additionally, the rise in cortical 5-HIAA levels might reflect stress-related increases in brain tryptophan influx.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biomedical Research-tokyo 医学-医学：研究与实验

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..