乳腺癌患者接受曲妥珠单抗治疗后出现具有黄氏变异型特征的皮肌炎病例报告。

IF 2.2 4区医学 Q2 DERMATOLOGY

Australasian Journal of Dermatology Pub Date : 2025-04-06 DOI:10.1111/ajd.14456

Lauren C LaMonica, Margaret E Lang Houser, Paul W Harms, Frank Wang

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引用次数: 0

摘要

药物诱发的皮肌炎与副肿瘤性皮肌炎很难区分。针对人表皮生长因子受体2（HER-2）的抗体（如曲妥珠单抗）可能会诱发皮肌炎，而免疫检查点抑制剂可能会诱发皮肌炎的Wong变异型，其临床和组织病理学特征为斑癣，包括单形角化性丘疹。我们介绍了一例不同寻常的皮肌炎病例，该病例发生在一名 51 岁的女性身上，她曾在完成曲妥珠单抗辅助治疗后患过乳腺癌。

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Case Report of Dermatomyositis With Features of the Wong Variant Developing Post-Trastuzumab Therapy for Breast Cancer.

Drug-induced dermatomyositis can be challenging to distinguish from paraneoplastic dermatomyositis. Rarely, antibodies directed against human epidermal growth factor receptor 2 (HER-2), such as trastuzumab, may trigger dermatomyositis, and immune checkpoint inhibitors may incite the Wong variant of dermatomyositis, characterised by clinical and histopathologic features of pityriasis rubra pilaris, including monomorphic keratotic papules. We present an unusual case of dermatomyositis with features of the Wong variant occurring in a 51-year-old female with a history of breast cancer after completion of adjuvant therapy with trastuzumab.

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来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.