康科德男性健康与老龄化项目(CHAMP) 5年随访中老年男性下尿路症状和排尿参数的自然病史

IF 6 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Giovanni Losco, Lewis Chan, Rachel Esler, Vasi Naganathan, Fiona Blyth
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引用次数: 0

摘要

背景:人们对排尿参数随年龄变化的自然历史了解甚少。我们的目的是了解5岁以上老年男性的主观和客观下尿路参数。方法:康科德男性健康与老龄化项目是一项老年男性的前瞻性队列研究,包括1705名生活在澳大利亚悉尼的70岁及以上男性。男性分别在0岁、2岁和5岁时接受评估。在三个时间点收集人口统计信息、病史、国际前列腺症状评分(IPSS)、血流率和空泡后容积。结果:共有1705名年龄在70-97岁的男性参与。在2年和5年的随访中,分别有1367名和940名男性接受了评估。平均IPSS基线为7.35,2年为6.96 (P = .9), 5年为7.18 (P = .30)。基线时的平均流速为15.0 ml/s, 2年时为14.6 ml/s (P = .001), 5年时为15.3 ml/s (P = .42)。调整基线年龄后,5年内的流量变化无统计学意义(P = 0.93)。平均空腔后残留在基线时为72.4 ml, 2年后为84.0 ml (P = 0.003), 5年后为93.2 ml (P = 0.001)。基线时剩余容量为bbb200 ml的男性在5年内剩余容量无显著变化(P = 0.51)。结论:泌尿系统症状和排尿参数在5年内保持稳定。空后容积升高的男性没有明显恶化。下尿路症状的保守治疗在老年男性中是一种合理的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Natural history of lower urinary tract symptoms and voiding parameters in ageing men with 5-year follow-up-the concord health and ageing in men project (CHAMP).

Background: Natural history of voiding parameters with age is poorly understood. We aim to understand both subjective and objective lower urinary tract parameters in older men over 5 years.

Methods: The Concord Health and Ageing in Men Project is a prospective cohort study of older men, involving 1705 men aged 70 years and over living in Sydney, Australia. Men were assessed at 0, 2 and 5 years. Demographic information, medical history, International Prostate Symptom Score (IPSS), flow rate and post-void volume were collected at three timepoints.

Results: A total of 1705 men aged 70-97 years participated. At 2 and 5 year follow-up, 1367 and 940 men presented for assessment. Mean IPSS was 7.35 at baseline, 6.96 at 2 years (P = .9) and 7.18 at 5 years (P = .30). Mean flow rate at baseline was 15.0 ml/s, 14.6 ml/s at 2 years (P = .001) and 15.3 ml/s at 5 years (P = .42). Adjusting for age at baseline, the change in flow over 5 years was not significant (P = .93). Mean post-void residual was 72.4 ml at baseline, 84.0 ml at 2 years (P = .003) and 93.2 ml at 5 years (P = .001). Men with residual volume >200 ml at baseline had no significant change in residual over 5 years (P = .51).

Conclusions: Urinary symptoms and voiding parameters remain stable over 5 years. Men with elevated post-void volume did not deteriorate significantly. Conservative management of lower urinary tract symptoms appears a reasonable strategy in older men.

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来源期刊
Age and ageing
Age and ageing 医学-老年医学
CiteScore
9.20
自引率
6.00%
发文量
796
审稿时长
4-8 weeks
期刊介绍: Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.
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