一种新型高选择性近红外探针的构建用于监测药物性肝损伤中谷胱甘肽水平的变化。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-03-27 DOI:10.1039/d5cc00870k

Zhiyuan Wang , Xiao Li , Suntao Shi , Ruipeng Shen , Yue Yang , Chunlin Sun , Zitong Liu , Haijuan Zhang , Baoxin Zhang

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引用次数: 0

摘要

药物性肝损伤（DILI）是急性肝功能衰竭的主要原因，与氧化应激密切相关。谷胱甘肽（GSH）是一种重要的巯基肽，能维持细胞氧化还原平衡和信号传导。在这项研究中，我们成功开发了一种高选择性的近红外荧光探针 AH-F，它在检测 GSH 时可将荧光增强 357 倍。在 AH-F 的帮助下，我们通过细胞和药物诱导的肝损伤鉴定了小鼠模型中的相关生理参数，同时还评估了相关药物干预措施的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Construction of a novel highly selective NIR probe for monitoring the changes of glutathione levels in drug-induced liver injury†

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Construction of a novel highly selective NIR probe for monitoring the changes of glutathione levels in drug-induced liver injury†

Drug-induced liver injury (DILI) is a leading cause of acute liver failure, which is closely associated with oxidative stress. Glutathione (GSH), a vital sulfhydryl peptide, maintains cellular redox balance and signaling. In this study, we have successfully developed a highly selective near-infrared fluorescent probe, , which exhibits a 357-fold enhancement in fluorescence upon detection of GSH. With the aid of , the pertinent physiological parameters in a murine model were characterized by cellular and drug-induced liver injury, concurrently allowing for the assessment of the therapeutic efficacy of relevant pharmaceutical interventions.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.