根瘤素通过胰岛素和SIR-2.1调控延长秀丽隐杆线虫的寿命。

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-03-24 eCollection Date: 2025-04-01 DOI:10.1021/acsomega.4c08725

Xiaohan Zhang, Hao Wang

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引用次数: 0

摘要

本研究以秀丽隐杆线虫为研究对象，探讨其潜在的抗衰老机制。结果表明，根霉素可减轻高温和过氧化氢的有害影响，降低氧化应激，提高抗氧化酶活性，降低丙二醛水平。网络药理学分析表明，AKT1、INSR和SOD2信号通路在根霉素的抗衰老作用中起关键作用。其作用由胰岛素和SIR-2.1介导，影响DAF-16、SKN-1等下游基因的抗衰老作用。这意味着苯连菌素是一种很有前途的功能性食品添加剂，针对DAF-16和SOD-3轴进行抗衰老。

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Phlorizin Prolongs the Lifespan of Caenorhabditis elegans by Insulin and SIR-2.1 Regulation.

Phlorizin has significant antioxidant properties and was studied using Caenorhabditis elegans to explore potential antiaging mechanisms. Results showed that phlorizin mitigated the harmful effects of high temperatures and hydrogen peroxide, reduced oxidative stress, increased antioxidant enzyme activity, and reduced malondialdehyde levels. Network pharmacological analysis reveals that the AKT1, INSR, and SOD2 signaling pathways play a key role in the antiaging effects of phlorizin. Its action is mediated by insulin and SIR-2.1, influencing DAF-16, SKN-1, and downstream genes in the antiaging effects. This implicates phlorizin as a promising functional food additive targeting the DAF-16 and SOD-3 axes for antiaging.

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.