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IF 6.8 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2025-04-07 DOI:10.1002/jmv.70323

Sunny Ssu-Yu Chen, Tina Ting-An Lin, Yi-Lin Chiang, Chien-Yun Chen, Hui-Yuan Chen, Yao-Min Hung, Renin Chang

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引用次数: 0

摘要

这项回顾性队列研究利用 TriNetX 美国合作数据库的数据评估了阻塞性睡眠呼吸暂停（OSA）与呼吸道合胞病毒（RSV）感染及其并发症风险之间的关联。通过 ICD-10-CM 编码确定了被诊断为 OSA 的患者（n = 1 061 261）和匹配的对照组（n = 3 479 494）。倾向评分匹配对 19 个协变量进行了调整，以平衡基线特征。在指数后 1 天到 1 年的随访期间，OSA 患者的 RSV 感染率明显更高（0.18% vs. 0.08%；HR：2.194，95% CI：2.025-2.378，p < 0.0001）。此外，OSA 患者出现严重 RSV 相关并发症的风险增加，包括呼吸衰竭（HR：1.291，95% CI：1.147-1.453）、住院（HR：1.114，95% CI：1.026-1.210）和入住重症监护室（HR：1.329，95% CI：1.118-1.579）。敏感性分析证实了这些发现在不同观察期、数据库子集、研究时间轴和纳入标准下的稳健性。按年龄和性别进行的分组分析也一致支持主要结果。这些研究结果表明，OSA 与 RSV 感染及相关严重后果的风险升高有关，这表明有必要开展进一步的研究来验证这些结果，并有可能将 OSA 患者列为 RSV 感染的高危人群。

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Obstructive Sleep Apnea and Risk of Respiratory Syncytial Viral Infection: A Retrospective Multi-Institution Cohort Study

This retrospective cohort study evaluated the association between obstructive sleep apnea (OSA) and the risk of respiratory syncytial virus (RSV) infection and its complications using data from the TriNetX US Collaborative Database. Patients diagnosed with OSA (n = 1 061 261) and matched controls (n = 3 479 494) were identified via ICD-10-CM codes. Propensity score matching adjusted for 19 covariates to balance baseline characteristics. Over a follow-up period ranging from 1 day to 1 year post-index, patients with OSA demonstrated a significantly higher incidence of RSV infection (0.18% vs. 0.08%; HR: 2.194, 95% CI: 2.025–2.378, p < 0.0001). Additionally, patients with OSA exhibited increased risks for severe RSV-related complications, including respiratory failure (HR: 1.291, 95% CI: 1.147–1.453), hospitalization (HR: 1.114, 95% CI: 1.026–1.210), and admission to critical care (HR: 1.329, 95% CI: 1.118–1.579). Sensitivity analyses confirmed the robustness of these findings across various observation periods, database subsets, study timelines, and inclusion criteria. Subgroup analyses stratified by age and gender also consistently supported the primary results. These findings suggest that OSA is associated with elevated risks of RSV infection and related severe outcomes, indicating the need for further studies to validate these results and potentially classify OSA patients as a high-risk group for RSV infection.

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.