海洋真菌青霉菌（Penicillium polonicum） kmm4719的生物活性喹啉酮生物碱

IF 1 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Applied Biochemistry and Microbiology Pub Date : 2025-04-07 DOI:10.1134/S0003683824605912

S. S. Starnovskaya, N. N. Kirichuk, V. E. Chausova, U. V. Khudyakova, E. A. Chingizova, A. R. Chingizov, A. N. Yurchenko, E. A. Yurchenko

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引用次数: 0

摘要

从海参Apostichopus japonicus中分离到一株海洋真菌kmm4719，经ITS、BenA和CaM分子遗传标记鉴定为polonicum。从菌株培养的乙酸乙酯萃取物中分离到3- o -甲基vi病菌素。3- o -甲基vi滑稽蛋白首次显示出心脏保护活性，并具有脲酶抑制活性（IC50为97.3 μM）。此外，浓度为100 μM （25.1 μg/mL）的3- o -甲基vipcatin对酵母样真菌白色念珠菌的生长抑制率为23.2%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Biologically Active Quinolinone Alkaloid from the Marine Fungus Penicillium polonicum KMM 4719

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Biologically Active Quinolinone Alkaloid from the Marine Fungus Penicillium polonicum KMM 4719

The marine fungal strain KMM 4719 was isolated from the sea cucumber Apostichopus japonicus and identified as Penicillium polonicum based on three molecular genetic markers: ITS, BenA, and CaM. 3-O-methylviridicatin was isolated from the ethyl acetate extract of the strain culture. 3-O-methylviridicatin has demonstrated cardioprotective activity for the first time, as well as urease inhibitory activity (IC₅₀ 97.3 μM). In addition, 3-O-methylviridicatin at a concentration of 100 μM (25.1 μg/mL) inhibited the growth of the yeast-like fungus Candida albicans at 23.2%.

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来源期刊

Applied Biochemistry and Microbiology 生物-生物工程与应用微生物

CiteScore

1.70

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.