Zhilei Zhang, Bo Li, Chunxia Zhang, Lu Li, Libin Cui, Peng Zhao, Yanjun Zhang, Jingang Song, Dingwei Zhang, Chao Wei, Yan Zhang, Liang Liu, Bing Zhao
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Nanotechnology for understanding the tumor microenvironment heterogeneity in bone carcinoma
Bone carcinoma face serious issues in its treatment owing to the complexity of the tumor microenvironment (TME) and the potential of bone metastasis. Nanotechnology provides potential strategies for addressing the intricacies and heterogeneity of tumor microenvironment in bone cancer. Recent developments in understanding the complexity of TME made it possible to precisely deliver onsite therapeutics for bone tumors, which minimized the side effects and improves the patient condition. Despite of the advancement, further exploration is needed for better therapeutic methods and preclinical research. To further enhance the detection and treatment of bone cancer, future research prospects include the progress in immunotherapies that specially targets bones and integrated therapeutic methods. This review will discuss the strategies and advancements in the diagnosis of bone carcinoma focusing on diagnostic imaging and targeted delivery of drugs for controlling and understanding of the tumor microenvironment.
期刊介绍：
Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field.
The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest.
Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials.
Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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