代谢特征的多样性及其与胶质瘤临床亚型的相关性

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2025-04-05 DOI:10.1016/j.semcancer.2025.03.008

Pushan Dasgupta, Vinay K. Puduvalli

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引用次数: 0

摘要

胶质瘤预后不佳，且已被证明难以治疗。目前针对单个信号通路的治疗和努力都失败了。这被认为是由于遗传和表观遗传异质性和抗性。因此，对神经胶质瘤中代表驱动因素和依赖性的代谢改变有了更深入的了解。针对胶质瘤特异性代谢依赖性的治疗克服了疾病异质性的挑战。在这里，我们提出不同的代谢特征，每个当前临床亚型胶质瘤。我们相信，这种方法将使开发新的策略能够利用这些代谢特征特异性地针对胶质瘤的各种临床和分子亚型。

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Diversity of metabolic features and relevance to clinical subtypes of gliomas

Gliomas carry a dismal prognosis and have proven difficult to treat. Current treatments and efforts to target individual signaling pathways have failed. This is thought to be due to genetic and epigenetic heterogeneity and resistance. Therefore, interest has grown in developing a deeper understanding of the metabolic alterations that represent drivers and dependencies in gliomas. Therapies that target glioma-specific metabolic dependencies overcome the challenges of disease heterogeneity. Here, we present the diverse metabolic features of each current clinical subtype of glioma. We believe that this approach will enable the development of novel strategies to specifically target the various clinical and molecular subtypes of glioma using these metabolic features.

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.