含阿育吠陀配方珊瑚的化疗恢复试剂盒在控制化疗不良反应和维持乳腺癌患者生活质量中的作用

IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Ayurveda and Integrative Medicine Pub Date : 2025-03-01 DOI:10.1016/j.jaim.2024.101012

Sadanand Sardeshmukh, Vineeta Deshmukh, Tushar Patil, Shweta Gujar, Vasanti Godse, Swapna Kulkarni, Shrinivas Datar, Dhananjay Deshpande, Nilambari Sardeshmukh, Sushma Bhuvad, Bhagyashree Sardeshmukh, Sandeep Chavan, Vidya Gupta

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引用次数: 0

摘要

乳腺癌是全球女性关注的主要问题之一。乳腺癌的治疗包括手术、化疗、激素治疗、靶向治疗和姑息治疗。虽然化疗是治疗的重要组成部分，但它也会引起不良反应，主要是由于化疗药物无法区分分裂的癌细胞和正常细胞，导致氧化应激增加和免疫状态受阻。目的探讨阿育吠陀药物治疗乳腺癌患者化疗不良反应的益处。材料与方法本回顾性研究纳入27例女性乳腺癌患者，均为手术、化疗、依从性纳入。这些患者被分为两组。研究组的13名患者接受阿育吠陀配方-含珊瑚的化学恢复试剂盒[作为草药矿物试剂盒申请印度专利（201921018273-已发表）和美国专利（17/ 609601 -已发表）]以及化疗治疗，而14名患者不提供任何额外的阿育吠陀药物，仅接受化疗治疗（对照组）。结果在常见的不良反应中，疲劳等症状有统计学上的显著改善(p <；0.0001)、呕吐（p = 0.001）、恶心（p = 0.003）和皮肤变色（p = 0.005）。其余症状如便秘、口炎和发烧在该组中也不太突出。卡诺夫斯基分数(p <；0.0001)，接受阿育吠陀药物治疗的患者的生活质量得到了很好的维持。结论珊瑚化疗恢复试剂盒对化疗引起的恶心、呕吐、疲劳、皮肤变色有较好的治疗效果，可提高患者的生活质量。

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Role of a Chemo-Recovery Kit with Ayurvedic formulations - containing coral in managing chemotherapy adverse effects and maintaining quality of life in breast cancer patients

Background

Breast cancer is one of the major concerns in women globally. Treatment for breast cancer comprises surgery, chemotherapy, hormonal therapy, targeted therapy, and palliative care. Though chemotherapy is an important component of treatment, it induces adverse effects, which are mainly caused by the inability of chemotherapeutic drugs to distinguish between dividing cancer cells and normal cells leading to increase in oxidative stress and hampered immune status.

Objective

To investigate the benefits of Ayurvedic medicines in breast cancer patients for managing chemotherapy adverse effects.

Material and methods

In this retrospective study, 27 female breast cancer patients who underwent surgery, posted for chemotherapy, and complying inclusion were included. These patients were divided into two groups. Study group of 13 patients were treated with Ayurvedic formulation - Chemo-Recovery Kit with coral [filed as a herbo-mineral kit for Indian patent (201921018273- published) and US Patent (17/609,601- published)] along with chemotherapy, while 14 patients were not provided with any additional Ayurvedic medicines and were treated with chemotherapy alone (control group).

Results

Out of commonly observed adverse effects, statistically significant improvement is noted in symptoms such as fatigue (p < 0.0001), vomiting (p = 0.001), nausea (p = 0.003) and skin discoloration (p = 0.005) in patients treated with adjunct Ayurvedic medicines. The remaining symptoms such as constipation, stomatitis and fever were also less prominent in this group. Karnofsky score (p < 0.0001) and quality of life assessed were well maintained in patients treated with Ayurvedic medicines.

Conclusion

Chemo-Recovery Kit with coral is highly effective in management of chemotherapy induced nausea, vomiting, fatigue and skin discoloration and thus to improve Quality of Life.

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