中国妊娠高血压和动脉粥样硬化性心血管疾病风险评分

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

CJC Open Pub Date : 2025-04-01 DOI:10.1016/j.cjco.2025.01.006

Honghong He MM , Junyan Sun MM , Hongqiu Huo MB , Yanxiu Wang MD , Yuntao Wu MM , Suhua Chen MB , Yangyang Wang MM , Xiaoming Zheng MD , Haiyan Zhao MD

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引用次数: 0

摘要

背景妊娠高血压（PIH）对孕产妇健康构成重大威胁。本研究旨在探讨PIH与动脉粥样硬化性心血管疾病（ASCVD）风险之间的关系。方法该队列包括2004年至2020年期间在开滦研究中分娩的1947名孕妇。参与者根据PIH病史分为PIH组和非PIH组（NPIH），在分娩后2年内完成问卷调查并进行体格检查和实验室评估。预测ASCVD风险使用中国动脉粥样硬化性心血管疾病风险（China- par）模型，将终生ASCVD风险区分为“低”（<32.8%）和“高”（≥32.8%）。采用χ2检验和logistic回归分析PIH与中国par高危险类别的相关性。结果总体而言，PIH组有6.17%的患者存在终生高危险，而NPIH组为0.96% (χ2 29.59, P <；0.001)。在调整混杂因素后，PIH与高风险的中国par类别独立相关，PIH组的概率比NPIH组高5.03倍(95% CI 2.20-11.51, P <；0.01)。结论妊娠高血压与ASCVD终生发病风险增高相关。

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Pregnancy-Induced Hypertension and Atherosclerotic Cardiovascular Disease Risk Score in China

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Pregnancy-Induced Hypertension and Atherosclerotic Cardiovascular Disease Risk Score in China

Background

Pregnancy-induced hypertension (PIH) poses a significant threat to maternal health. This study aims to explore the association between PIH and the risk of atherosclerotic cardiovascular disease (ASCVD).

Methods

The cohort comprised 1947 pregnant women delivering a single child between 2004 and 2020 in the Kailuan study. Participants, categorized into PIH and non-PIH (NPIH) groups based on PIH history, completed questionnaires and underwent physical examinations and laboratory assessments within 2 years after delivery. Predicted ASCVD risks used the Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) model, distinguishing lifetime ASCVD risk as "low" (<32.8%) and "high" (≥32.8%). χ² tests and logistic regression were used to investigate the association between PIH and high lifetime risk China-PAR categories.

Results

Overall, 6.17% of the PIH group had high lifetime risk, compared with 0.96% in the NPIH group (χ² 29.59, P < 0.001). After adjusting for confounders, PIH was independently associated with high-risk China-PAR categories, with the PIH group having a 5.03 times higher probability than the NPIH group (95% CI 2.20-11.51, P < 0.01).