从有和没有情绪障碍史的成年人的静息状态连接数据中识别儿童虐待的恢复力特征

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science Pub Date : 2025-03-04 DOI:10.1016/j.bpsgos.2025.100479

Mindy Westlund Schreiner , Leah R. Thomas , Ha D.H. Le , Myah Pazdera , Daniel A. Feldman , Brian Farstead , Katie L. Bessette , Robert C. Welsh , Sheila E. Crowell , Erin A. Kaufman , Heide Klumpp , Scott A. Langenecker

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引用次数: 0

摘要

儿童虐待（CM）与负面的心理健康结果相关。许多研究将弹性定义为经历CM而不发展精神病理（初级弹性）。然而，有些人可能会出现后续的精神病理，但会恢复并表现出更高的整体功能（次生弹性）。本研究探讨了显著性和情绪网络（SEN）（包括杏仁核、亚属前扣带皮层和岛叶前部）和认知控制网络（CCN）（包括背外侧前额叶皮层、下顶叶和丘脑）连通性在初级和次级弹性中的作用。方法研究了108名非临床对照和154名心境障碍患者的静息状态功能连通性。我们分别使用整体功能评估量表（GAF）和儿童创伤问卷（CTQ）来测量功能和CM。对于初级弹性，我们对SEN和CCN区域进行了全脑分析，以测试组与CTQ的相互作用。对于二次弹性，amd组内分析测试了CTQ × GAF相互作用。结果组与CTQ的相互作用显示，CM水平较高的对照组参与者比AMD组的参与者表现出更大的sen和ccn内连通性。在AMD组中，具有较高CM水平和功能（次级弹性）的参与者表现出更大的ccn内连通性，而具有较高CM水平和较低功能的参与者表现出更大的sen内连通性。结论：正如在对照组中观察到的那样，更大的SEN连通性似乎在初级恢复力中起关键作用，但仅在更大的CCN连通性的背景下。未来的工作应该探索哪些认知控制特征是最有益的，以及有针对性的干预是否有助于培养对复发性精神病理的恢复能力。

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Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder

Background

Childhood maltreatment (CM) is associated with negative mental health outcomes. Many studies conceptualize resilience as experiencing CM without developing psychopathology (primary resilience). However, some people may develop subsequent psychopathology but recover and demonstrate higher global functioning (secondary resilience). This study investigated the role of salience and emotion network (SEN) (including the amygdala, subgenual anterior cingulate cortex, and anterior insula) and cognitive control network (CCN) (including the dorsolateral prefrontal cortex, inferior parietal lobule, and thalamus) connectivity in primary and secondary resilience.

Methods

We examined resting-state functional connectivity in 108 nonclinical control participants and 154 individuals with any mood disorder (AMD). We measured functioning and CM using the Global Assessment of Functioning (GAF) scale and the Childhood Trauma Questionnaire (CTQ), respectively. For primary resilience, we conducted whole-brain analyses of SEN and CCN regions to test for group × CTQ interactions. For secondary resilience, within-AMD group analyses tested for CTQ × GAF interactions.

Results

Group × CTQ interactions revealed that control participants with higher levels of CM showed greater within-SEN and within-CCN connectivity than participants in the AMD group. In the AMD group, participants with higher levels of CM and functioning (secondary resilience) showed greater within-CCN connectivity while participants with higher levels of CM and lower functioning showed greater within-SEN connectivity.

Conclusions

Greater SEN connectivity appears to play a key role in primary resilience, as observed in the control group, but only within the context of greater CCN connectivity. Future work should explore which cognitive control features are most beneficial and whether targeted interventions help foster resilience to recurrent psychopathology.

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来源期刊

Biological psychiatry global open science Psychiatry and Mental Health

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

91 days