ReLEx®SMILE®微创手术中透镜体的生物力学特性：年龄和近视程度有影响吗？

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-04-01 DOI:10.1016/j.clinbiomech.2025.106508

V.S. Kukanova , A.K. Dzamikhova , A.A. Akovantseva , A.A. Frolova , Yu.M. Efremov , T. Yu Shilova , A.A. Svistunov , S.E. Avetisov , P.S. Timashev , S.L. Kotova

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引用次数: 0

摘要

近视是目前最常见的眼部屈光性疾病。角膜生物力学参数在近视中的重要作用早已被认识，ReLEx®SMILE微创屈光手术为角膜生物力学研究提供了新的可能性。有关年龄和近视程度对角膜生物力学的影响的文献报道并不一致。方法采用原子力显微镜、微测仪、拉伸试验等方法，对不同年龄、不同近视程度患者的smile源性晶状体进行了检测，共122例。发现：透镜体的力学性能变化很大，并且因使用的技术不同而不同。皮囊前后两侧的杨氏模量无差异。在一些研究中发现的与年龄相关的角膜硬化在我们的研究中没有被记录，我们的研究样本是150例年龄在17岁到47岁之间的患者。在高应变条件下，中、高度近视的透镜体拉伸模量明显降低，而其他技术没有发现相关性。结构原子力显微镜成像研究显示胶原原纤维大多是混沌的3D网络，而粗糙度与近视严重程度无关。研究表明，年龄和近视程度对角膜的力学性能和形态没有根本的影响。文献中报告的结果不一致是由于实验数据的高度分散和测量技术的特殊性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomechanical properties of lenticules in the ReLEx® SMILE® minimally invasive surgery: Do the age and degree of myopia matter?

Background

Myopia is currently the most common refractive disorder of the eye. The important role of the cornea's biomechanical parameters in relation to myopia has long been acknowledged, and ReLEx® SMILE minimally invasive refractive surgery offers new possibilities in the corneal biomechanical studies. The reported data on the role of the age and myopia degree in the corneal biomechanics are inconsistent.

Methods

We have examined a considerable number (122 in total) of SMILE-derived lenticules from patients of different ages and with different severity of myopia, using atomic force microscopy, microtester and tensile testing.

Findings

The mechanical properties of lenticules varied in a wide range and differed for the different techniques used. No differences between the Young's moduli of the anterior and posterior sides of lenticules were observed. The age-related stiffening of the cornea found in some studies was not registered in our study, with >150 samples of patients aged from 17 to 47 years. Significantly lower tensile moduli of lenticules from moderate and high myopic eyes were measured by tensile testing in high-strain conditions, while no correlation was found using other techniques. The structural atomic force microscopy imaging studies demonstrated a mostly chaotic 3D network of collagen fibrils, while the roughness was independent of the myopia severity.

Interpretation

No fundamental effect of the age and myopia degree on the corneal mechanical properties and morphology has been shown. The inconsistency of findings reported in the literature are due to the high dispersion of experimental data and specifics of the measurement techniques.

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.