麝香籽提取物减轻肥胖雄性大鼠肝脏氧化负荷,改善胰岛素敏感性

Q3 Medicine
Sherif A. Abdelmottaleb Moussa , Fatma A.A. Ibrahim , Marawan Abd Elbaset , Fatma A. Morsy , Samir W. Aziz , Noha A. Abd El-Latif , Sherif M. Afifi , Tuba Esatbeyoglu , Sayed A. El Toumy , Josline Y. Salib , Samir A.E. Bashandy
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引用次数: 0

摘要

百里香,属于兰科,是一种值得注意的草药,具有多种用途。本研究探讨寻常胸腺种子提取物对肥胖大鼠肝脏氧化负荷、胰岛素敏感性和肝功能的影响。普通赤霉素治疗组,特别是高剂量(400mg /kg)组,与肥胖组相比,腰围、体重和BMI都有明显减少。在降低炎症标志物的同时,黄皮草种子提取物的补充显示出脂质谱、胰岛素抵抗、肝功能和抗氧化状态的显著改善。肝组织的组织病理学检查证实了寻常草种子提取物的治疗作用,如改善肝脏结构和减少肥胖引起的有害变化所示。以甲氧基黄酮为主要代谢物,采用液相色谱-质谱法鉴定了32种代谢物。综上所述,冬草籽提取物具有良好的抗肥胖作用,影响肥胖大鼠的人体测量指标、血脂、胰岛素抵抗、肝功能以及炎症和肝脏氧化应激标志物。这项研究的最终结论是,寻常草种子在控制肥胖相关并发症方面具有潜在的治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats
Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.
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来源期刊
Endocrine and Metabolic Science
Endocrine and Metabolic Science Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.80
自引率
0.00%
发文量
4
审稿时长
84 days
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