类风湿关节炎诊断前的血清蛋白质组学特征表明进化的生物学途径并确定疾病发展的特定时期

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2025-04-06 DOI:10.1002/art.43175

Samir Rachid Zaim, Adam K. Savage, Mark A. Gillespie, Jazmine Castillo, Christy Bennett, Troy R Torgerson, Lynne A. Becker, Michael Mahler, LauraKay Moss, Marie L. Feser, Jess D. Edison, Ted R. Mikuls, V. Michael Holers, Xiao-jun Li, Kevin D. Deane

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引用次数: 0

摘要

本纵向病例对照研究评估了临床诊断类风湿关节炎（即ra前期）之前的血清蛋白质组学，以评估疾病发展的生物学途径，并为预测未来疾病的发病时间提供信息。

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Serum proteomic signatures prior to the diagnosis of rheumatoid arthritis demonstrate evolving biological pathways and identify specific periods of disease development

This longitudinal case-control study evaluated serum proteomics prior to a clinical diagnosis of rheumatoid arthritis (i.e. pre-RA) to evaluate biologic pathways of disease development and inform prediction of timing of onset of future disease.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.