狼疮性肾炎 II:治疗和监测。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI:10.1016/bs.acc.2025.01.001
Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma
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引用次数: 0

摘要

系统性红斑狼疮(SLE)、狼疮肾炎(LN)的肾脏受累是常见的,可导致显著的发病率,包括进行性肾功能障碍,甚至最终导致死亡。LN是异质性的,并伴有免疫成分,准确分类LN对指导最佳治疗至关重要。因此,识别客观标记对于反映疾病分期和监测治疗反应至关重要。在本系列的第二部分中,我们将全面探讨LN疾病的分类、治疗方法和潜在的标志物,以指导治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lupus nephritis II: Treatment and monitoring.

Renal involvement in systemic lupus erythematosus (SLE), lupus nephritis (LN), is common and can result in significant morbidity, including progressive renal dysfunction, and even ultimately leading to death. LN is heterogeneous complicated by the immunologic component, and it is critical to accurately classify LN to direct optimal therapy. Accordingly, identification of objective markers is paramount in reflecting disease stage and monitoring treatment response. In part two of this series, we comprehensively examine LN disease classification, therapies and potential markers to guide therapeutic options.

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