Steven Schepanski, Gonza B Ngoumou, Anna Katharina Koch, Marleen Schröter, Robert Roehle, Georg Seifert
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引用次数: 0
摘要
背景：慢性炎症是一个重要的公共卫生问题，在儿童和青少年中，它增加了各种不同健康问题的长期风险。虽然身心疗法如瑜伽、冥想和针灸在调节成人免疫反应方面显示出希望，但它们在儿科人群中的安全性和有效性仍未得到充分探索。本方案概述了旨在评估身心疗法对儿童和青少年免疫调节的影响的系统综述和荟萃分析的方法。方法：本系统综述和荟萃分析将遵循PRISMA 2020指南。我们将纳入随机对照试验、非随机对照试验、队列研究和病例对照研究，以检查儿科人群中身心治疗与免疫标记物之间的关系。电子检索将在MEDLINE、Embase、PsycINFO、CINAHL、Web of Science和Cochrane图书馆进行，并辅以试验登记。将使用Cochrane偏倚风险工具（RoB 1）、非随机干预研究的偏倚风险（ROBINS-I）和纽卡斯尔-渥太华量表（NOS）评估偏倚风险。两名独立审稿人将筛选研究，提取数据，评估研究质量，第三名审稿人解决任何差异。结果将综合叙述和通过meta分析使用R软件。讨论：本综述将评价身心疗法对儿童和青少年免疫标记物的有效性和安全性。综合证据将指导临床实践和公共卫生政策，将身心疗法纳入儿科护理。研究结果也将为该领域未来的研究和政策制定提供基础。系统评价注册：PROSPERO CRD42024546585。
Mind-body therapies and their interplay with the immune system in children and adolescents: a protocol for a systematic review and meta-analysis.
Background: Chronic inflammation is a critical public health concern that, in children and adolescents, increases the long-term risk of a variety of different health issues. While mind-body therapies like yoga, meditation, and acupuncture have shown promise in modulating immune responses in adults, their safety and effectiveness in pediatric populations remain underexplored. This protocol outlines the methodology for a systematic review and meta-analysis aimed at evaluating the effects of mind-body therapies on immune modulation in children and adolescents.
Methods: This systematic review and meta-analysis will follow PRISMA 2020 guidelines. We will include randomized controlled trials, non-randomized controlled trials, cohort studies, and case-control studies that examine the relationship between mind-body therapies and immune markers in pediatric populations. Electronic searches will be conducted in MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, and the Cochrane Library, supplemented by trial registries. Risk of bias will be assessed using the Cochrane Risk of Bias Tool (RoB 1), the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I), and the Newcastle-Ottawa Scale (NOS). Two independent reviewers will screen studies, extract data, and assess study quality, with a third reviewer resolving any discrepancies. Results will be synthesized both narratively and through meta-analysis using R software.
Discussion: The review will evaluate the effectiveness and safety of mind-body therapies on immune markers in children and adolescents. The synthesized evidence will guide clinical practice and public health policies in integrating mind-body therapies into pediatric care. The findings will also provide a foundation for future research and policymaking in this area.
期刊介绍：
Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.
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