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IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Supportive Care in Cancer Pub Date : 2025-04-05 DOI:10.1007/s00520-025-09394-w

Amber S Kleckner, Carin L Clingan, Shari M Youngblood, Ian R Kleckner, Lauren Quick, Rebecca D Elrod, Shijun Zhu, Emily N C Manoogian, Satchidananda Panda, Ashraf Z Badros, Ashkan Emadi

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引用次数: 0

摘要

目的：限时进食（TRE）有助于调节休息-活动节奏、血糖和其他昼夜调节的能量过程，这可能会对持续疲劳产生影响。在一项随机对照试验中，我们测试了 TRE 与对照组相比对癌症幸存者疲劳的影响：方法：我们招募了治疗后 2 个月至 2 年的成年癌症幸存者，他们均报告有中度至重度疲劳。参与者按 1:1 的比例随机分组，即 TRE 组和对照组，所有参与者都接受了个性化营养咨询。TRE组自行选择10小时的进食时间，为期12周。在基线、第6周和第12周，参与者被要求记录进食情况，完成慢性病治疗功能评估--疲劳问卷（FACIT-F，得分越高=疲劳越少），并佩戴行动计和连续血糖监测仪：30 名参与者完成了基线评估并被随机分组（77% 为女性，53% 为黑人/非裔美国人，43% 为白人，7% 为西班牙裔美国人；54.1 ± 14.7 岁；87% 患有血癌）；25 名参与者完成了为期 12 周的评估。在控制基线水平的情况下，TRE 可在第 12 周显著降低疲劳程度（对照组 FACIT-F 疲劳分量表的变化 = 0.0 ± 5.4，TRE 的变化 = 4.1 ± 5.7，P = 0.11，效应大小 (ES) = 0.70；有临床意义的阈值 = 3.0 分）。在第6周和第12周，TRE组与对照组相比，血糖参数（如平均间质葡萄糖、平均空腹血糖）往往更低，休息-活动节奏往往更有规律，但差异无统计学意义（P > 0.19）：结论：与对照组相比，营养师指导的为期 12 周的 TRE 计划可减少疲劳。有必要继续研究 TRE 模式，以优化这种饮食模式，解决与癌症有关的持续疲劳问题：试验注册：ClinicalTrials.gov Identifier：NCT05256888.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Time-restricted eating to address persistent cancer-related fatigue among cancer survivors: a randomized controlled trial.

Purpose: Time-restricted eating (TRE) helps regulate rest-activity rhythms, blood glucose, and other diurnally regulated energetics processes, which may have implications for persistent fatigue. In a randomized controlled trial, we tested the effects of TRE vs. control on fatigue in cancer survivorship.

Methods: Adult cancer survivors were recruited who were 2 months to 2 years post-treatment and reported moderate to severe fatigue. Participants were randomized 1:1, TRE:control, and all received individualized nutrition counseling. The TRE group self-selected a 10-h eating window for 12 weeks. At baseline, week 6, and week 12, participants were asked to log eating instances, complete the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire (FACIT-F, higher score = less fatigue), and wear an actigraph and continuous glucose monitor.

Results: Thirty participants completed baseline assessments and were randomized (77% female, 53% Black/African American, 43% White, 7% Hispanic; 54.1 ± 14.7 years old; 87% with blood cancer); 25 completed 12-week assessments. TRE led to a meaningful reduction in fatigue at week 12 controlling for baseline levels (change in FACIT-F fatigue subscale = 0.0 ± 5.4 for control, 4.1 ± 5.7 for TRE, p = 0.11, effect size (ES) = 0.70; clinically meaningful threshold = 3.0 points). Glucose parameters (e.g., average interstitial glucose, average fasting glucose) tended to be lower, and rest-activity rhythms tended to indicate more regularity for those in the TRE vs. control group at weeks 6 and 12, though differences were not statistically significant (p > 0.19).

Conclusions: A 12-week, nutritionist-led TRE program led to less fatigue than control. Continued study of TRE patterns are warranted to optimize this eating pattern and address persistent cancer-related fatigue.

Trial registration: ClinicalTrials.gov Identifier: NCT05256888.

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.