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IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Supportive Care in Cancer Pub Date : 2025-04-05 DOI:10.1007/s00520-025-09422-9

Xin Dan, Tang-Lin Chen, Ya-Lin Tian, Yan Huang, Jian-Hua Ren, Ru-Tie Yin, Ya-Lin He

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引用次数: 0

摘要

背景：化疗引起的恶心和呕吐（CINV）大大降低了接受早期和晚期癌症治疗患者的生活质量（QoL）。尽管采取了预防性止吐措施，但 CINV 仍是一项挑战，且反应率有限。CINV 不仅会对患者的身体健康造成不利影响，还会影响他们的心理健康、社会交往和治疗依从性：本研究旨在评估无呕吐病房倡议对管理 CINV 的影响及其对接受化疗的妇科癌症患者的心理健康和 QoL 的影响：本研究从2023年1月至12月选取了960名在四川省首屈一指的妇产科医院接受住院化疗的妇科肿瘤患者。根据入院日期将患者平均分为干预组和对照组。两组均接受标准护理，而干预组则遵循无呕吐病房方案。采用多国癌症支持性护理协会（MASCC）止吐工具、功能性生活指数（FLIE）和医院焦虑抑郁量表（HADS）对该专门病房的效果进行了评估：与对照组相比，干预组的急性和延迟性 CINV 发生频率和严重程度均有明显改善。此外，严重恶心和呕吐对休闲活动的影响分别减少了9.7%和7.2%，中度至重度恶心和呕吐对日常生活的影响分别减少了6.9%和8.6%。与标准护理相比，无呕吐病房的引入显著降低了患者的焦虑水平（t = - 3.148，P < 0.001）和抑郁水平（t = - 3.223，P < 0.001）：无呕吐病房的实施有效缓解了妇科肿瘤患者的恶心和呕吐，提高了患者的生活质量，减少了焦虑和抑郁。这种创新方法可融入临床实践，为医护人员提供有价值的见解和指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Developing and assessing a vomiting-free ward workflow for gynecological patients receiving chemotherapy.

Background: Chemotherapy-induced nausea and vomiting (CINV) significantly diminishes the quality of life (QoL) for patients undergoing early and late-stage cancer treatments. Despite preventive antiemetic measures, CINV remains a challenge, with limited response rates. CINV adversely affects not only patients' physical health but also their psychological well-being, social interactions, and treatment adherence.

Objective: This study aimed to evaluate the impact of a vomiting-free ward initiative on managing CINV and its effects on the psychological well-being and QoL of gynecological cancer patients receiving chemotherapy.

Method: In this study, 960 gynecological oncology patients receiving inpatient chemotherapy at a premier obstetrics and gynecology hospital in Sichuan Province were enrolled from January to December 2023. They were evenly divided into intervention and control groups based on their admission dates. Both groups underwent standard care, and the intervention group followed a vomiting-free ward protocol. The effectiveness of this specialized ward was evaluated using the Multinational Association of Supportive Care in Cancer (MASCC) Antiemesis Tool, the Functional Living Index-Emesis (FLIE), and the Hospital Anxiety and Depression Scale (HADS).

Results: The intervention group showed significant improvements in the frequency and severity of both acute and delayed CINV compared to the control group. Furthermore, there was a 9.7% and 7.2% decrease in the impact of severe nausea and vomiting on leisure activities and a 6.9% and 8.6% reduction in how moderate to severe nausea and vomiting affected daily living, respectively. The introduction of the vomiting-free ward significantly reduced levels of patient anxiety (t = - 3.148, P < 0.001) and depression (t = - 3.223, P < 0.001) compared to standard care.

Conclusion: The implementation of a vomiting-free ward effectively mitigates nausea and vomiting, enhances QoL, and decreases anxiety and depression among gynecological oncology patients. This innovative approach can be integrated into clinical practice, providing valuable insights and guidelines for healthcare professionals.

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.