Omolola Salako, Muhammad Y Habeebu, Paul T Okediji, Adaorah F Enyi, Kehinde S Okunade, Gabriel T Fagbenro, Blossom A Maduafokwa, Oghenekome O Agha, Kamaldeen Abdulraheem, Matthew J Allsop
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引用次数: 0
摘要
背景：化疗、免疫治疗和放疗等癌症治疗方法会产生严重的不良反应，影响患者的生理功能和身体外观，造成经济损失，降低生活质量，并增加中断治疗的风险。本系统性综述旨在描述与非手术癌症治疗相关的副作用，以及影响非洲癌症患者副作用严重程度的临床因素：方法：通过四个数据库（Medline (PubMed)、ClinicalTrials.gov、Embase 和 Cochrane Central Register of Controlled Trials）对报告非洲国家化疗、放疗、激素治疗、靶向治疗和免疫治疗副作用的主要研究进行了系统检索：在 7870 篇已确定的文章中，有 51 项符合条件的研究被纳入其中。文章概述了化疗（31 例）、放疗（6 例）、化放疗（9 例）、化疗和靶向治疗（2 例）以及化疗、放疗和靶向治疗（3 例）的副作用。据报道，最常见的副作用是恶心和呕吐（化疗）、放射性皮炎（放疗）、中性粒细胞减少症和贫血（化学放疗）。纳入的研究报告显示，副作用风险的增加与联合治疗（即化疗放疗）、化疗类型、较高的累积化疗剂量、较频繁的治疗周期以及合并症的存在有关。六项研究表明，因治疗相关副作用而中断治疗的情况时有发生：综述强调，癌症治疗提供者需要预测治疗相关副作用并提前减轻副作用，提供必要的预防措施和治疗支持。
A systematic review and meta-analysis of side effects influenced by non-surgical treatments in African cancer patients.
Background: Cancer treatments such as chemotherapy immunotherapy and radiotherapy are associated with serious adverse effects that affect a patient's physiological functioning and physical appearance, contribute to financial toxicity, reduce quality of life, and increase the risk of treatment discontinuation. This systematic review aims to describe treatment-related side effects associated with non-surgical cancer treatment and clinical factors that influence the severity of side effects experienced among African cancer patients.
Method: A systematic search of primary research studies reporting side effects of chemotherapy, radiotherapy, hormone therapy, targeted therapy, and immunotherapy among patients in African countries was undertaken across four databases (Medline (PubMed), ClinicalTrials.gov, Embase, and Cochrane Central Register of Controlled Trials).
Results: Of the 7870 identified articles, 51 eligible studies were included . Articles outlined side effects from chemotherapy (n = 31), radiotherapy (n = 6), chemoradiation (n = 9), chemotherapy and targeted therapy (n = 2), and chemotherapy, radiotherapy, and targeted therapy (n = 3). The most prevalent side effects reported were nausea and vomiting (chemotherapy), radiation dermatitis (radiotherapy), neutropenia, and anaemia (chemoradiation). Included studies reported an increased risk of side effects related to combined therapy (i.e., chemoradiation), type of chemotherapy, higher cumulative chemotherapy doses, more frequent treatment cycles, and the presence of comorbidities. Six studies indicated treatment discontinuation arising due to treatment-related side effects.
Conclusion: The review highlights the need for cancer care providers to anticipate treatment-related side effects and mitigate them ahead of time, providing necessary prophylactic measures and treatment support.
期刊介绍：
Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease.
Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.
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