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IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-04-03 DOI:10.1016/j.molmed.2025.03.007

Christos Adamopoulos, Kostas A Papavassiliou, Athanasios G Papavassiliou

引用次数: 0

摘要

Maciag 等人最近在《癌症发现》（Cancer Discovery）杂志上发表的一项研究中介绍了一种新型抑制剂 BBO-8520，它同时针对 KRASG12C 的活性和非活性状态。这种双重抑制显示出卓越的靶点参与性和持久的肿瘤抑制作用，为克服 KRASG12C 突变癌症的耐药性发展和改善预后提供了一种令人信服的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Targeting the Yin and Yang of KRAS^G12C.

In a recent study in Cancer Discovery, Maciag et al. introduce BBO-8520, a novel inhibitor targeting both the active and inactive states of KRAS^G12C. This dual inhibition shows superior target engagement and prolonged tumor suppression, offering a compelling strategy to overcome resistance development and improve outcomes in KRAS^G12C-mutant cancers.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.