新冠肺炎对儿童脑影响的多模态MRI分析。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Ting Peng, Chaowei Zhang, Pingping Xie, Ying Lin, Lin Zhang, Zuozhen Lan, Mingwen Yang, Xianghui Huang, Jungang Liu, Guoqiang Cheng
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引用次数: 0

摘要

COVID-19大流行引起了人们对其对包括大脑在内的中枢神经系统的影响的严重担忧。虽然对成年人的影响有充分的记录,但对儿科人群的影响知之甚少。本研究调查了轻度COVID-19儿童皮质指标和基于局部旋转指数(LGI)的结构协方差网络(scn)的变化,以及与淋巴功能相关的非侵入性MRI指标的变化。我们招募了19名患有COVID-19的儿童和22名年龄相当的健康对照。获得高分辨率t1加权和弥散加权MRI图像。皮质指标,包括厚度、表面积、体积和LGI,使用顶点方向的一般线性模型进行比较。分析scn在整体和节点指标上的差异,并评估MRI指标,包括沿血管周围空间和脉络膜丛(CP)体积的扩散张量成像。我们的研究结果显示,在患有COVID-19的儿童中,左侧顶叶上皮层的皮质面积、体积和LGI增加,左侧枕侧皮层的皮质厚度增加。SCN分析显示,COVID组的网络拓扑改变,CP体积更大,提示病毒诱导的神经炎症。这些发现为轻度COVID-19后儿童的潜在大脑改变提供了证据,强调需要进一步研究长期神经发育结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multimodal MRI analysis of COVID-19 effects on pediatric brain.

Multimodal MRI analysis of COVID-19 effects on pediatric brain.

Multimodal MRI analysis of COVID-19 effects on pediatric brain.

Multimodal MRI analysis of COVID-19 effects on pediatric brain.

The COVID-19 pandemic has raised significant concerns regarding its impact on the central nervous system, including the brain. While the effects on adult populations are well documented, less is known about its implications for pediatric populations. This study investigates alterations in cortical metrics and structural covariance networks (SCNs) based on the Local Gyrification Index (LGI) in children with mild COVID-19, alongside changes in non-invasive MRI proxies related to glymphatic function. We enrolled 19 children with COVID-19 and 22 age-comparable healthy controls. High-resolution T1-weighted and diffusion-weighted MRI images were acquired. Cortical metrics, including thickness, surface area, volume, and LGI, were compared using vertex-wise general linear models. SCNs were analyzed for differences in global and nodal metrics, and MRI proxies, including diffusion tensor imaging along the perivascular space and choroid plexus (CP) volume, were also assessed. Our results showed increased cortical area, volume, and LGI in the left superior parietal cortex, as well as increased cortical thickness in the left lateral occipital cortex among children with COVID-19. SCN analysis revealed altered network topology and larger CP volumes in the COVID group, suggesting virus-induced neuroinflammation. These findings provide evidence of potential brain alterations in children following mild COVID-19, emphasizing the need for further investigation into long-term neurodevelopmental outcomes.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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