Fatemeh Rastegar Jooybari, Christopher Huynh, Sharon Portnoy, Jonathan Voutsas, Diana Balmer-Minnes, Ankavipar Saprungruang, Shi-Joon Yoo, Christopher Z Lam, Christopher K Macgowan
{"title":"具有呼吸代偿和心脏视图共享的高加速4D血流MRI：儿童先天性心脏病大血管血流的横断面研究","authors":"Fatemeh Rastegar Jooybari, Christopher Huynh, Sharon Portnoy, Jonathan Voutsas, Diana Balmer-Minnes, Ankavipar Saprungruang, Shi-Joon Yoo, Christopher Z Lam, Christopher K Macgowan","doi":"10.1007/s00247-025-06226-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Conventional four-dimensional (4D) flow magnetic resonance imaging (MRI) is limited by long scan times, particularly in pediatric congenital heart disease (CHD) patients.</p><p><strong>Objective: </strong>This study evaluates accelerated 4D flow MRI incorporating respiratory compensation and cardiac view sharing in healthy adults and pediatric CHD patients.</p><p><strong>Materials and methods: </strong>Subjects underwent 5-min free-breathing protocol with a three-dimensional (3D) radial trajectory and compressed sensing reconstruction. The 4D flow MRI reconstruction pipeline was improved by respiratory soft-gating and cardiac view sharing. Flow in major thoracic vessels was compared with two-dimensional (2D) phase contrast MRI, the reference standard.</p><p><strong>Results: </strong>Fourteen pediatric CHD patients (median age: 13 years (interquartile range (IQR): 5)) and four healthy adult volunteers (median age: 26 years (IQR: 3)) were recruited. Soft-gating improved diaphragm sharpness and reduced respiratory-induced blur (image quality scores: healthy: 46.1 soft-gated vs. 47.2 non-gated; CHD: 47.8 soft-gated vs. 48.2 non-gated). View sharing reduced undersampling artifacts and enhanced the signal-to-noise ratio (SNR, healthy: +9.9%; CHD: +3.8%). In healthy adults, correlations with 2D phase contrast MRI were strong for mean flow (R<sup>2</sup>=0.94, slope=0.94±0.12, root mean square error (RMSE)=6.4 ml/s; bias=1.1±6.4 ml/s, P=0.45) and peak flow (R<sup>2</sup>=0.9, slope=0.86±0.13, RMSE=40.9 ml/s; bias=21.3±44.7 ml/s, P=0.04). Similarly, CHD patients showed a strong correlation for mean flow (R<sup>2</sup>=0.88, slope=0.93±0.09, RMSE=8.3 ml/s) and peak flow (R<sup>2</sup>=0.97, slope=0.98±0.03, RMSE=25.9 ml/s). Internal consistency for 4D flow MRI in CHD cases showed mean percent differences of 6.1% Main pulmonary artery=Left pulmonary artery+Right pulmonary artery and 6.5% Ascending aorta=Descending aorta+Superior vena cava.</p><p><strong>Conclusion: </strong>The accelerated 4D flow MRI method provides robust flow quantification and visualization in pediatric CHD patients, strongly correlating with 2D phase contrast MRI and completing scans in 5 min for clinical use.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Highly accelerated 4D flow MRI with respiratory compensation and cardiac view sharing: a cross-sectional study of flow in the great vessels of pediatric congenital heart disease.\",\"authors\":\"Fatemeh Rastegar Jooybari, Christopher Huynh, Sharon Portnoy, Jonathan Voutsas, Diana Balmer-Minnes, Ankavipar Saprungruang, Shi-Joon Yoo, Christopher Z Lam, Christopher K Macgowan\",\"doi\":\"10.1007/s00247-025-06226-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Conventional four-dimensional (4D) flow magnetic resonance imaging (MRI) is limited by long scan times, particularly in pediatric congenital heart disease (CHD) patients.</p><p><strong>Objective: </strong>This study evaluates accelerated 4D flow MRI incorporating respiratory compensation and cardiac view sharing in healthy adults and pediatric CHD patients.</p><p><strong>Materials and methods: </strong>Subjects underwent 5-min free-breathing protocol with a three-dimensional (3D) radial trajectory and compressed sensing reconstruction. The 4D flow MRI reconstruction pipeline was improved by respiratory soft-gating and cardiac view sharing. Flow in major thoracic vessels was compared with two-dimensional (2D) phase contrast MRI, the reference standard.</p><p><strong>Results: </strong>Fourteen pediatric CHD patients (median age: 13 years (interquartile range (IQR): 5)) and four healthy adult volunteers (median age: 26 years (IQR: 3)) were recruited. Soft-gating improved diaphragm sharpness and reduced respiratory-induced blur (image quality scores: healthy: 46.1 soft-gated vs. 47.2 non-gated; CHD: 47.8 soft-gated vs. 48.2 non-gated). View sharing reduced undersampling artifacts and enhanced the signal-to-noise ratio (SNR, healthy: +9.9%; CHD: +3.8%). In healthy adults, correlations with 2D phase contrast MRI were strong for mean flow (R<sup>2</sup>=0.94, slope=0.94±0.12, root mean square error (RMSE)=6.4 ml/s; bias=1.1±6.4 ml/s, P=0.45) and peak flow (R<sup>2</sup>=0.9, slope=0.86±0.13, RMSE=40.9 ml/s; bias=21.3±44.7 ml/s, P=0.04). Similarly, CHD patients showed a strong correlation for mean flow (R<sup>2</sup>=0.88, slope=0.93±0.09, RMSE=8.3 ml/s) and peak flow (R<sup>2</sup>=0.97, slope=0.98±0.03, RMSE=25.9 ml/s). Internal consistency for 4D flow MRI in CHD cases showed mean percent differences of 6.1% Main pulmonary artery=Left pulmonary artery+Right pulmonary artery and 6.5% Ascending aorta=Descending aorta+Superior vena cava.</p><p><strong>Conclusion: </strong>The accelerated 4D flow MRI method provides robust flow quantification and visualization in pediatric CHD patients, strongly correlating with 2D phase contrast MRI and completing scans in 5 min for clinical use.</p>\",\"PeriodicalId\":19755,\"journal\":{\"name\":\"Pediatric Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00247-025-06226-1\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00247-025-06226-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
Highly accelerated 4D flow MRI with respiratory compensation and cardiac view sharing: a cross-sectional study of flow in the great vessels of pediatric congenital heart disease.
Background: Conventional four-dimensional (4D) flow magnetic resonance imaging (MRI) is limited by long scan times, particularly in pediatric congenital heart disease (CHD) patients.
Objective: This study evaluates accelerated 4D flow MRI incorporating respiratory compensation and cardiac view sharing in healthy adults and pediatric CHD patients.
Materials and methods: Subjects underwent 5-min free-breathing protocol with a three-dimensional (3D) radial trajectory and compressed sensing reconstruction. The 4D flow MRI reconstruction pipeline was improved by respiratory soft-gating and cardiac view sharing. Flow in major thoracic vessels was compared with two-dimensional (2D) phase contrast MRI, the reference standard.
Results: Fourteen pediatric CHD patients (median age: 13 years (interquartile range (IQR): 5)) and four healthy adult volunteers (median age: 26 years (IQR: 3)) were recruited. Soft-gating improved diaphragm sharpness and reduced respiratory-induced blur (image quality scores: healthy: 46.1 soft-gated vs. 47.2 non-gated; CHD: 47.8 soft-gated vs. 48.2 non-gated). View sharing reduced undersampling artifacts and enhanced the signal-to-noise ratio (SNR, healthy: +9.9%; CHD: +3.8%). In healthy adults, correlations with 2D phase contrast MRI were strong for mean flow (R2=0.94, slope=0.94±0.12, root mean square error (RMSE)=6.4 ml/s; bias=1.1±6.4 ml/s, P=0.45) and peak flow (R2=0.9, slope=0.86±0.13, RMSE=40.9 ml/s; bias=21.3±44.7 ml/s, P=0.04). Similarly, CHD patients showed a strong correlation for mean flow (R2=0.88, slope=0.93±0.09, RMSE=8.3 ml/s) and peak flow (R2=0.97, slope=0.98±0.03, RMSE=25.9 ml/s). Internal consistency for 4D flow MRI in CHD cases showed mean percent differences of 6.1% Main pulmonary artery=Left pulmonary artery+Right pulmonary artery and 6.5% Ascending aorta=Descending aorta+Superior vena cava.
Conclusion: The accelerated 4D flow MRI method provides robust flow quantification and visualization in pediatric CHD patients, strongly correlating with 2D phase contrast MRI and completing scans in 5 min for clinical use.
期刊介绍：
Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology
Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described.
Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.
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