{"title":"超高分辨率光子计数检测器CT血管造影提高未破裂颅内动脉瘤的诊断准确性和更好的形态学表征。","authors":"Naying He, Haiying Lyu, Youmin Zhang, Ruixi Li, Zhihan Xu, Ewart Mark Haacke, Ying Cui, Jiqiang Li, Haipeng Dong, Wentao Han, Rui Chang, Zhen Hu, Chengcheng Zhu, Zhangsheng Yu, Yong Lu, Hong Jiang, Fuhua Yan","doi":"10.1136/jnis-2025-023094","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Accurate detection and morphology evaluation of unruptured intracranial aneurysms (UIAs) are essential for patient management. This study aimed to assess the efficacy of ultra-high-resolution (UHR) photon-counting detector-CT angiography (PCD-CTA) in detecting UIAs and characterizing their morphological features.</p><p><strong>Methods: </strong>This prospective study recruited consecutive participants suspected of cerebral vascular diseases who underwent PCD-CTA and subsequent digital subtraction angiography (DSA) within 1 month from September 2023 to May 2024. Performance of UIA diagnosis using UHR PCD-CTA images (slice thickness 0.2 mm) and standard resolution (SR, reflecting clinical protocols) reconstructed images were compared with DSA as reference on a per-participant, per-vessel, and per-aneurysm basis. The inter-rater agreement for UIA detection and aneurysm morphology characterization using UHR/SR PCD-CTA was also evaluated.</p><p><strong>Results: </strong>Among 95 participants, 50 UIAs were confirmed in 42 participants using DSA. The inter-rater agreement for UIA detection was: kappa 0.95 for UHR and 0.89 for SR (p<0.05). On a per-aneurysm basis, the sensitivity, specificity, and diagnostic accuracy of UHR (98.0%, 96.7%, 97.3%) were all significantly higher than SR (72.0%, 86.7%, 80.0%) (p<0.05). UHR PCD-CTA accurately identified 13 of the 14 aneurysms (93%) missed by SR PCD-CTA, including 3 cases (21%) larger than 3 mm. Furthermore, UHR identified more aneurysm irregularity (18/50, 36%) than SR (5/50, 10%) (p=0.004). UHR also revealed 4 (8.0%) more cases with wall calcification and 3 (6.0%) more cases with intra-aneurysmal hypointensity (possible thrombus) than SR.</p><p><strong>Conclusions: </strong>The advantages of UHR PCD-CTA, including enhanced reliability, improved diagnostic accuracy, and more comprehensive information, have the potential to significantly optimize UIA management.</p>","PeriodicalId":16411,"journal":{"name":"Journal of NeuroInterventional Surgery","volume":" ","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Increased diagnostic accuracy and better morphology characterization of unruptured intracranial aneurysm by ultra-high-resolution photon-counting detector CT angiography.\",\"authors\":\"Naying He, Haiying Lyu, Youmin Zhang, Ruixi Li, Zhihan Xu, Ewart Mark Haacke, Ying Cui, Jiqiang Li, Haipeng Dong, Wentao Han, Rui Chang, Zhen Hu, Chengcheng Zhu, Zhangsheng Yu, Yong Lu, Hong Jiang, Fuhua Yan\",\"doi\":\"10.1136/jnis-2025-023094\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Accurate detection and morphology evaluation of unruptured intracranial aneurysms (UIAs) are essential for patient management. This study aimed to assess the efficacy of ultra-high-resolution (UHR) photon-counting detector-CT angiography (PCD-CTA) in detecting UIAs and characterizing their morphological features.</p><p><strong>Methods: </strong>This prospective study recruited consecutive participants suspected of cerebral vascular diseases who underwent PCD-CTA and subsequent digital subtraction angiography (DSA) within 1 month from September 2023 to May 2024. Performance of UIA diagnosis using UHR PCD-CTA images (slice thickness 0.2 mm) and standard resolution (SR, reflecting clinical protocols) reconstructed images were compared with DSA as reference on a per-participant, per-vessel, and per-aneurysm basis. The inter-rater agreement for UIA detection and aneurysm morphology characterization using UHR/SR PCD-CTA was also evaluated.</p><p><strong>Results: </strong>Among 95 participants, 50 UIAs were confirmed in 42 participants using DSA. The inter-rater agreement for UIA detection was: kappa 0.95 for UHR and 0.89 for SR (p<0.05). On a per-aneurysm basis, the sensitivity, specificity, and diagnostic accuracy of UHR (98.0%, 96.7%, 97.3%) were all significantly higher than SR (72.0%, 86.7%, 80.0%) (p<0.05). UHR PCD-CTA accurately identified 13 of the 14 aneurysms (93%) missed by SR PCD-CTA, including 3 cases (21%) larger than 3 mm. Furthermore, UHR identified more aneurysm irregularity (18/50, 36%) than SR (5/50, 10%) (p=0.004). UHR also revealed 4 (8.0%) more cases with wall calcification and 3 (6.0%) more cases with intra-aneurysmal hypointensity (possible thrombus) than SR.</p><p><strong>Conclusions: </strong>The advantages of UHR PCD-CTA, including enhanced reliability, improved diagnostic accuracy, and more comprehensive information, have the potential to significantly optimize UIA management.</p>\",\"PeriodicalId\":16411,\"journal\":{\"name\":\"Journal of NeuroInterventional Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of NeuroInterventional Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/jnis-2025-023094\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROIMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of NeuroInterventional Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/jnis-2025-023094","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROIMAGING","Score":null,"Total":0}
Increased diagnostic accuracy and better morphology characterization of unruptured intracranial aneurysm by ultra-high-resolution photon-counting detector CT angiography.
Background: Accurate detection and morphology evaluation of unruptured intracranial aneurysms (UIAs) are essential for patient management. This study aimed to assess the efficacy of ultra-high-resolution (UHR) photon-counting detector-CT angiography (PCD-CTA) in detecting UIAs and characterizing their morphological features.
Methods: This prospective study recruited consecutive participants suspected of cerebral vascular diseases who underwent PCD-CTA and subsequent digital subtraction angiography (DSA) within 1 month from September 2023 to May 2024. Performance of UIA diagnosis using UHR PCD-CTA images (slice thickness 0.2 mm) and standard resolution (SR, reflecting clinical protocols) reconstructed images were compared with DSA as reference on a per-participant, per-vessel, and per-aneurysm basis. The inter-rater agreement for UIA detection and aneurysm morphology characterization using UHR/SR PCD-CTA was also evaluated.
Results: Among 95 participants, 50 UIAs were confirmed in 42 participants using DSA. The inter-rater agreement for UIA detection was: kappa 0.95 for UHR and 0.89 for SR (p<0.05). On a per-aneurysm basis, the sensitivity, specificity, and diagnostic accuracy of UHR (98.0%, 96.7%, 97.3%) were all significantly higher than SR (72.0%, 86.7%, 80.0%) (p<0.05). UHR PCD-CTA accurately identified 13 of the 14 aneurysms (93%) missed by SR PCD-CTA, including 3 cases (21%) larger than 3 mm. Furthermore, UHR identified more aneurysm irregularity (18/50, 36%) than SR (5/50, 10%) (p=0.004). UHR also revealed 4 (8.0%) more cases with wall calcification and 3 (6.0%) more cases with intra-aneurysmal hypointensity (possible thrombus) than SR.
Conclusions: The advantages of UHR PCD-CTA, including enhanced reliability, improved diagnostic accuracy, and more comprehensive information, have the potential to significantly optimize UIA management.
期刊介绍：
The Journal of NeuroInterventional Surgery (JNIS) is a leading peer review journal for scientific research and literature pertaining to the field of neurointerventional surgery. The journal launch follows growing professional interest in neurointerventional techniques for the treatment of a range of neurological and vascular problems including stroke, aneurysms, brain tumors, and spinal compression.The journal is owned by SNIS and is also the official journal of the Interventional Chapter of the Australian and New Zealand Society of Neuroradiology (ANZSNR), the Canadian Interventional Neuro Group, the Hong Kong Neurological Society (HKNS) and the Neuroradiological Society of Taiwan.
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