具有保护镍肾损伤作用的新型天然益生菌:重金属中毒的一种策略。

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shokufeh Beglari, Niloofar Rezaie, Fatemeh Haririzadeh Jouriani, Elham Haj Agha Gholizadeh Khiavi, Shadi Aghamohammad, Mahdi Rohani
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引用次数: 0

摘要

最近的研究表明,接触重金属,特别是镍,会增加氧化应激,从而加剧肾脏疾病。益生菌因其抗氧化特性而被公认,可能提供一种有益的方法来减轻这种氧化损伤。本研究旨在探讨天然益生菌在降低肾组织氧化应激中的作用,从而为改善肾脏对重金属毒性的保护策略提供潜在的依据。在这项研究中,40只雄性NMRI小鼠暴露于镍诱导氧化应激,然后进行益生菌处理,以评估其潜在的保护作用。这些干预措施对抗氧化系统的影响通过Real-Time PCR分析来评估,该分析测量了小鼠肾组织中的基因表达谱。研究表明,天然益生菌菌株在暴露于氧化剂前可有效上调Nrf2信号通路相关基因的表达。尽管镍暴露对这些基因表达有抑制作用,但在镍暴露后给予益生菌可显著增加和增强这些基因的表达水平。本研究强调了重金属镍对肾脏健康的有害影响,同时探索了益生菌的保护特性,特别是其抗氧化作用。考虑到与重金属暴露相关的重大风险,益生菌的整合提供了一种有希望的策略来缓解氧化应激,从而潜在地预防与这种情况相关的各种肾脏疾病。研究结果提倡通过益生菌干预来解决重金属毒性和增强肾脏恢复能力的双重方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel native probiotics with protective effects against nickel-induced kidney injury: a strategy for heavy metal toxicity.

Recent studies have shown that exposure to heavy metals, particularly Nickel, and exacerbates kidney diseases by increasing oxidative stress. Probiotics, recognized for their antioxidant properties, may provide a beneficial approach to mitigate this oxidative damage. This research aims to explore the efficacy of native probiotics in reducing oxidative stress in kidney tissues, potentially leading to improved protective strategies against the toxicity caused by heavy metals. In this study, forty male NMRI mice were exposed to Nickel to induce oxidative stress, followed by probiotic treatment to evaluate its potential protective effects. The impact of these interventions on the antioxidant system was assessed through Real-Time PCR analysis, which measured gene expression profiles in the kidney tissue of the mice. The study demonstrated that native probiotic strains effectively upregulated the expression of genes related to Nrf2 signaling pathway before exposing to oxidant agents. Despite the suppressive effects of Nickel exposure on these gene expressions, the subsequent administration of probiotics after Nickel resulted in a significant increase and enhancement of expression levels. This research underscores the detrimental effects of Nickel, a heavy metal, on kidney health while exploring the protective properties of probiotics, particularly their anti-oxidative effects. Given the substantial risks linked to heavy metal exposure, the integration of probiotics presents a promising strategy to alleviate oxidative stress, thereby potentially preventing various kidney disorders associated with this condition. The findings advocate for a dual approach of addressing heavy metal toxicity and enhancing kidney resilience through probiotic intervention.

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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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