Yuto Uchida, Zhipeng Hou, Laura Gomez-Isaza, Maria Luongo, Juan C. Troncoso, Michael I. Miller, Susumu Mori, Kenichi Oishi
{"title":"定量穿孔路径纤维对阿尔茨海默病的早期检测","authors":"Yuto Uchida, Zhipeng Hou, Laura Gomez-Isaza, Maria Luongo, Juan C. Troncoso, Michael I. Miller, Susumu Mori, Kenichi Oishi","doi":"10.1002/alz.70142","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>The entorhinal cortex (ERC) and perforant path (PP) fibers are critical structures in the pathology of Alzheimer's disease (AD). This study aims to explore these regions using high-field magnetic resonance imaging (MRI), with the goal of identifying reliable biomarkers based on histopathological observations.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Twenty <i>post mortem</i> brain specimens were scanned with 11.7T MRI, including diffusion tensor imaging and tractography, and were cut for subsequent histological examinations. The entorhinal cortical thickness and number of PP fibers derived from MRI were compared across neuropathological and <i>premortem</i> clinical diagnoses of AD.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>The entorhinal cortical thickness and number of PP fibers decreased along with severities of neurofibrillary tangles in the ERC. Meanwhile, a reduction in the number of PP fibers, but not the entorhinal cortical thickness, was observed during the preclinical stage of AD.</p>\n </section>\n \n <section>\n \n <h3> CONCLUSIONS</h3>\n \n <p>Degeneration of PP fibers was observed in early AD and progressed along with neuropathological changes.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>\n <p>Twenty <i>post mortem</i> brain tissues were scanned with 11.7T MRI.</p>\n </li>\n \n <li>\n <p>Degeneration of PP fibers was observed at 250 µm isotropic resolution.</p>\n </li>\n \n <li>\n <p>PP fiber indices were linked with severities of NFTs.</p>\n </li>\n \n <li>\n <p>The number of PP fibers was decreased in preclinical AD.</p>\n </li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70142","citationCount":"0","resultStr":"{\"title\":\"Quantification of perforant path fibers for early detection of Alzheimer's disease\",\"authors\":\"Yuto Uchida, Zhipeng Hou, Laura Gomez-Isaza, Maria Luongo, Juan C. Troncoso, Michael I. Miller, Susumu Mori, Kenichi Oishi\",\"doi\":\"10.1002/alz.70142\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>The entorhinal cortex (ERC) and perforant path (PP) fibers are critical structures in the pathology of Alzheimer's disease (AD). This study aims to explore these regions using high-field magnetic resonance imaging (MRI), with the goal of identifying reliable biomarkers based on histopathological observations.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>Twenty <i>post mortem</i> brain specimens were scanned with 11.7T MRI, including diffusion tensor imaging and tractography, and were cut for subsequent histological examinations. The entorhinal cortical thickness and number of PP fibers derived from MRI were compared across neuropathological and <i>premortem</i> clinical diagnoses of AD.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>The entorhinal cortical thickness and number of PP fibers decreased along with severities of neurofibrillary tangles in the ERC. Meanwhile, a reduction in the number of PP fibers, but not the entorhinal cortical thickness, was observed during the preclinical stage of AD.</p>\\n </section>\\n \\n <section>\\n \\n <h3> CONCLUSIONS</h3>\\n \\n <p>Degeneration of PP fibers was observed in early AD and progressed along with neuropathological changes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>\\n <p>Twenty <i>post mortem</i> brain tissues were scanned with 11.7T MRI.</p>\\n </li>\\n \\n <li>\\n <p>Degeneration of PP fibers was observed at 250 µm isotropic resolution.</p>\\n </li>\\n \\n <li>\\n <p>PP fiber indices were linked with severities of NFTs.</p>\\n </li>\\n \\n <li>\\n <p>The number of PP fibers was decreased in preclinical AD.</p>\\n </li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 4\",\"pages\":\"\"},\"PeriodicalIF\":13.0000,\"publicationDate\":\"2025-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70142\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/alz.70142\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70142","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Quantification of perforant path fibers for early detection of Alzheimer's disease
INTRODUCTION
The entorhinal cortex (ERC) and perforant path (PP) fibers are critical structures in the pathology of Alzheimer's disease (AD). This study aims to explore these regions using high-field magnetic resonance imaging (MRI), with the goal of identifying reliable biomarkers based on histopathological observations.
METHODS
Twenty post mortem brain specimens were scanned with 11.7T MRI, including diffusion tensor imaging and tractography, and were cut for subsequent histological examinations. The entorhinal cortical thickness and number of PP fibers derived from MRI were compared across neuropathological and premortem clinical diagnoses of AD.
RESULTS
The entorhinal cortical thickness and number of PP fibers decreased along with severities of neurofibrillary tangles in the ERC. Meanwhile, a reduction in the number of PP fibers, but not the entorhinal cortical thickness, was observed during the preclinical stage of AD.
CONCLUSIONS
Degeneration of PP fibers was observed in early AD and progressed along with neuropathological changes.
Highlights
Twenty post mortem brain tissues were scanned with 11.7T MRI.
Degeneration of PP fibers was observed at 250 µm isotropic resolution.
PP fiber indices were linked with severities of NFTs.
The number of PP fibers was decreased in preclinical AD.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
