{"title":"虚弱和抑郁与认知功能的多重轨迹：来自健康和退休纵向研究的发现","authors":"Chengxiang Hu, Xiaoyue Sun, Zhirong Li, Yue He, Beibei Han, Zibo Wu, Siyu Liu, Lina Jin","doi":"10.1002/jcsm.13795","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Little is known about the joint associations between trajectories of frailty and depression with cognitive function. This study aims to explore the multitrajectories of frailty and depression and their joint impact on cognition.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A total of 8600 participants from the Health and Retirement Study (HRS) (1996–2018) were analysed using a group-based trajectory model for 10-year multitrajectories. Participants were classified into five groups based on their trajectories. Multivariable linear mixed models and Cox proportional hazards models were utilized.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Compared with Group 1 (stable robust and nondepressed), Groups 2 (‘worsening prefrailty without depression,’ <i>β</i> = −0.022 SD/year), 3 (‘stable prefrailty with escalating depressive symptoms,’ <i>β</i> = −0.016 SD/year), 4 (‘increasing frailty alongside worsening depressive symptoms,’ <i>β</i> = −0.034 SD/year) and 5 (‘high and escalating frailty with persistent depression,’ <i>β</i> = −0.055 SD/year) exhibited accelerated cognitive decline. Dementia risk was significantly higher in G2 (HR = 1.26, 95% CI: 1.08–1.48), G3 (HR = 1.54, 95% CI: 1.31–1.80), G4 (HR = 1.81, 95% CI: 1.54–2.14) and G5 (HR = 1.86, 95% CI: 1.48–2.33) compared with G1.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Worsening frailty and depression accelerate cognitive decline and risk of dementia, underscoring the need to address both conditions to mitigate cognition.</p>\n </section>\n </div>","PeriodicalId":48911,"journal":{"name":"Journal of Cachexia Sarcopenia and Muscle","volume":"16 2","pages":""},"PeriodicalIF":9.4000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcsm.13795","citationCount":"0","resultStr":"{\"title\":\"Multitrajectories of Frailty and Depression With Cognitive Function: Findings From the Health and Retirement Longitudinal Study\",\"authors\":\"Chengxiang Hu, Xiaoyue Sun, Zhirong Li, Yue He, Beibei Han, Zibo Wu, Siyu Liu, Lina Jin\",\"doi\":\"10.1002/jcsm.13795\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Little is known about the joint associations between trajectories of frailty and depression with cognitive function. This study aims to explore the multitrajectories of frailty and depression and their joint impact on cognition.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A total of 8600 participants from the Health and Retirement Study (HRS) (1996–2018) were analysed using a group-based trajectory model for 10-year multitrajectories. Participants were classified into five groups based on their trajectories. Multivariable linear mixed models and Cox proportional hazards models were utilized.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Compared with Group 1 (stable robust and nondepressed), Groups 2 (‘worsening prefrailty without depression,’ <i>β</i> = −0.022 SD/year), 3 (‘stable prefrailty with escalating depressive symptoms,’ <i>β</i> = −0.016 SD/year), 4 (‘increasing frailty alongside worsening depressive symptoms,’ <i>β</i> = −0.034 SD/year) and 5 (‘high and escalating frailty with persistent depression,’ <i>β</i> = −0.055 SD/year) exhibited accelerated cognitive decline. Dementia risk was significantly higher in G2 (HR = 1.26, 95% CI: 1.08–1.48), G3 (HR = 1.54, 95% CI: 1.31–1.80), G4 (HR = 1.81, 95% CI: 1.54–2.14) and G5 (HR = 1.86, 95% CI: 1.48–2.33) compared with G1.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Worsening frailty and depression accelerate cognitive decline and risk of dementia, underscoring the need to address both conditions to mitigate cognition.</p>\\n </section>\\n </div>\",\"PeriodicalId\":48911,\"journal\":{\"name\":\"Journal of Cachexia Sarcopenia and Muscle\",\"volume\":\"16 2\",\"pages\":\"\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2025-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcsm.13795\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cachexia Sarcopenia and Muscle\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jcsm.13795\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cachexia Sarcopenia and Muscle","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jcsm.13795","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Multitrajectories of Frailty and Depression With Cognitive Function: Findings From the Health and Retirement Longitudinal Study
Background
Little is known about the joint associations between trajectories of frailty and depression with cognitive function. This study aims to explore the multitrajectories of frailty and depression and their joint impact on cognition.
Methods
A total of 8600 participants from the Health and Retirement Study (HRS) (1996–2018) were analysed using a group-based trajectory model for 10-year multitrajectories. Participants were classified into five groups based on their trajectories. Multivariable linear mixed models and Cox proportional hazards models were utilized.
Results
Compared with Group 1 (stable robust and nondepressed), Groups 2 (‘worsening prefrailty without depression,’ β = −0.022 SD/year), 3 (‘stable prefrailty with escalating depressive symptoms,’ β = −0.016 SD/year), 4 (‘increasing frailty alongside worsening depressive symptoms,’ β = −0.034 SD/year) and 5 (‘high and escalating frailty with persistent depression,’ β = −0.055 SD/year) exhibited accelerated cognitive decline. Dementia risk was significantly higher in G2 (HR = 1.26, 95% CI: 1.08–1.48), G3 (HR = 1.54, 95% CI: 1.31–1.80), G4 (HR = 1.81, 95% CI: 1.54–2.14) and G5 (HR = 1.86, 95% CI: 1.48–2.33) compared with G1.
Conclusions
Worsening frailty and depression accelerate cognitive decline and risk of dementia, underscoring the need to address both conditions to mitigate cognition.
期刊介绍：
The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing materials related to cachexia and sarcopenia, as well as body composition and its physiological and pathophysiological changes across the lifespan and in response to various illnesses from all fields of life sciences. The journal aims to provide a reliable resource for professionals interested in related research or involved in the clinical care of affected patients, such as those suffering from AIDS, cancer, chronic heart failure, chronic lung disease, liver cirrhosis, chronic kidney failure, rheumatoid arthritis, or sepsis.
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