Katherine I. Tierney, Jennifer Therrien, Stephanie Ellwood, Lisa Graves
{"title":"美国年轻人口中生育率影响癌症发病率的不平等","authors":"Katherine I. Tierney, Jennifer Therrien, Stephanie Ellwood, Lisa Graves","doi":"10.1002/cam4.70797","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Infertility is a concerning late effect of cancer and cancer treatments, yet referrals for fertility preservation are unequal across U.S. sociodemographic groups. Although all-site cancer incidence varies across U.S. sociodemographic groups, it is unclear whether fertility-impacting cancers, specifically, are unevenly distributed by sex or race/ethnicity.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Cross-sectional analysis of cancer registry data from the Surveillance, Epidemiology, and End Results (SEER) Program (2010–2020). Age-specific demographic rates and negative binomial regression with an exposure for population size were employed to assess inequalities in the incidence rates of fertility-impacting cancers among U.S. individuals aged 39 and younger. Wald tests were used to compare coefficients across the multivariable negative binomial regression models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Women had higher incidence rates of fertility-impacting cancers (cancers of the reproductive organs, cancers in areas proximal to the reproductive organs or that contribute to reproductive functioning, and other cancers identified in the literature as fertility-impacting) in the fully adjusted models. These associations differed from the patterns observed among all other types of cancers. The incidence rates of fertility-impacting cancers also varied by race/ethnic groups. However, the patterning observed by race-ethnicity varied between the three fertility-impacting cancer groups.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The burden of fertility-impacting cancers is unequal across sex and race/ethnic groups. The sociodemographic patterns observed in fertility-impacting cancers differ substantively from cancers that were not identified as fertility-impacting. The findings reinforce the importance of screening for fertility-impacting cancers and identify a potential unmet need for both fertility preservation referrals among cancer patients and access to fertility treatment for survivors of cancer.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 7","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70797","citationCount":"0","resultStr":"{\"title\":\"Inequalities in Fertility-Impacting Cancer Incidence Among Young Populations in the United States\",\"authors\":\"Katherine I. Tierney, Jennifer Therrien, Stephanie Ellwood, Lisa Graves\",\"doi\":\"10.1002/cam4.70797\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Infertility is a concerning late effect of cancer and cancer treatments, yet referrals for fertility preservation are unequal across U.S. sociodemographic groups. Although all-site cancer incidence varies across U.S. sociodemographic groups, it is unclear whether fertility-impacting cancers, specifically, are unevenly distributed by sex or race/ethnicity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Cross-sectional analysis of cancer registry data from the Surveillance, Epidemiology, and End Results (SEER) Program (2010–2020). Age-specific demographic rates and negative binomial regression with an exposure for population size were employed to assess inequalities in the incidence rates of fertility-impacting cancers among U.S. individuals aged 39 and younger. Wald tests were used to compare coefficients across the multivariable negative binomial regression models.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Women had higher incidence rates of fertility-impacting cancers (cancers of the reproductive organs, cancers in areas proximal to the reproductive organs or that contribute to reproductive functioning, and other cancers identified in the literature as fertility-impacting) in the fully adjusted models. These associations differed from the patterns observed among all other types of cancers. The incidence rates of fertility-impacting cancers also varied by race/ethnic groups. However, the patterning observed by race-ethnicity varied between the three fertility-impacting cancer groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The burden of fertility-impacting cancers is unequal across sex and race/ethnic groups. The sociodemographic patterns observed in fertility-impacting cancers differ substantively from cancers that were not identified as fertility-impacting. The findings reinforce the importance of screening for fertility-impacting cancers and identify a potential unmet need for both fertility preservation referrals among cancer patients and access to fertility treatment for survivors of cancer.</p>\\n </section>\\n </div>\",\"PeriodicalId\":139,\"journal\":{\"name\":\"Cancer Medicine\",\"volume\":\"14 7\",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70797\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cam4.70797\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cam4.70797","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Inequalities in Fertility-Impacting Cancer Incidence Among Young Populations in the United States
Introduction
Infertility is a concerning late effect of cancer and cancer treatments, yet referrals for fertility preservation are unequal across U.S. sociodemographic groups. Although all-site cancer incidence varies across U.S. sociodemographic groups, it is unclear whether fertility-impacting cancers, specifically, are unevenly distributed by sex or race/ethnicity.
Methods
Cross-sectional analysis of cancer registry data from the Surveillance, Epidemiology, and End Results (SEER) Program (2010–2020). Age-specific demographic rates and negative binomial regression with an exposure for population size were employed to assess inequalities in the incidence rates of fertility-impacting cancers among U.S. individuals aged 39 and younger. Wald tests were used to compare coefficients across the multivariable negative binomial regression models.
Results
Women had higher incidence rates of fertility-impacting cancers (cancers of the reproductive organs, cancers in areas proximal to the reproductive organs or that contribute to reproductive functioning, and other cancers identified in the literature as fertility-impacting) in the fully adjusted models. These associations differed from the patterns observed among all other types of cancers. The incidence rates of fertility-impacting cancers also varied by race/ethnic groups. However, the patterning observed by race-ethnicity varied between the three fertility-impacting cancer groups.
Conclusion
The burden of fertility-impacting cancers is unequal across sex and race/ethnic groups. The sociodemographic patterns observed in fertility-impacting cancers differ substantively from cancers that were not identified as fertility-impacting. The findings reinforce the importance of screening for fertility-impacting cancers and identify a potential unmet need for both fertility preservation referrals among cancer patients and access to fertility treatment for survivors of cancer.
期刊介绍：
Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas:
Clinical Cancer Research
Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations
Cancer Biology:
Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery.
Cancer Prevention:
Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach.
Bioinformatics:
Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers.
Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
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