{"title":"抗人乳头瘤病毒药物预防宫颈癌的研究进展","authors":"Hangdi Chen, Kai Guo, Zhihao Bai, Liuyi Lu, Bin Liu, Jiali Zhang, Meiyin Zhong, Changfen Xu, Wanghuan Chen, Aiwu Huang, Yuemin Ding","doi":"10.1002/cam4.70847","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low-income countries. Secondary prevention through screening faces challenges in public engagement, often leading to late-stage diagnoses. Recent advancements in novel anti-HPV drugs offer expanded opportunities for cervical cancer management.</p>\n </section>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>This review examines emerging anti-HPV therapeutics to provide insights into innovative strategies for cervical cancer prevention and treatment.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We conducted a systematic analysis of published studies investigating anti-HPV agents, focusing on their molecular mechanisms and clinical efficacy in cervical cancer prevention.</p>\n </section>\n \n <section>\n \n <h3> Results & Conclusions</h3>\n \n <p>Multiple promising anti-HPV agents have been identified, including 3-hydroxyphthalic anhydride-modified bovine β-lactoglobulin (3HP-β-LG), carrageenan, defensins, and 25-hydroxycholesterol (25HC). These compounds exert antiviral effects through distinct mechanisms: 3HP-β-LG competitively inhibits viral attachment, carrageenan blocks HPV entry via heparan sulfate mimicry, defensins inhibit the dissociation of viral capsid, and 25HC activates cholesterol-mediated antiviral pathways. They have demonstrated strong inhibitory effects on HPV infection, making them novel therapeutic candidates for the prevention and treatment of cervical cancer.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 7","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70847","citationCount":"0","resultStr":"{\"title\":\"Advances in the Prevention of Cervical Cancer by Anti-Human Papillomavirus Agents\",\"authors\":\"Hangdi Chen, Kai Guo, Zhihao Bai, Liuyi Lu, Bin Liu, Jiali Zhang, Meiyin Zhong, Changfen Xu, Wanghuan Chen, Aiwu Huang, Yuemin Ding\",\"doi\":\"10.1002/cam4.70847\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low-income countries. Secondary prevention through screening faces challenges in public engagement, often leading to late-stage diagnoses. Recent advancements in novel anti-HPV drugs offer expanded opportunities for cervical cancer management.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>This review examines emerging anti-HPV therapeutics to provide insights into innovative strategies for cervical cancer prevention and treatment.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We conducted a systematic analysis of published studies investigating anti-HPV agents, focusing on their molecular mechanisms and clinical efficacy in cervical cancer prevention.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results & Conclusions</h3>\\n \\n <p>Multiple promising anti-HPV agents have been identified, including 3-hydroxyphthalic anhydride-modified bovine β-lactoglobulin (3HP-β-LG), carrageenan, defensins, and 25-hydroxycholesterol (25HC). These compounds exert antiviral effects through distinct mechanisms: 3HP-β-LG competitively inhibits viral attachment, carrageenan blocks HPV entry via heparan sulfate mimicry, defensins inhibit the dissociation of viral capsid, and 25HC activates cholesterol-mediated antiviral pathways. They have demonstrated strong inhibitory effects on HPV infection, making them novel therapeutic candidates for the prevention and treatment of cervical cancer.</p>\\n </section>\\n </div>\",\"PeriodicalId\":139,\"journal\":{\"name\":\"Cancer Medicine\",\"volume\":\"14 7\",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70847\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cam4.70847\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cam4.70847","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Advances in the Prevention of Cervical Cancer by Anti-Human Papillomavirus Agents
Background
Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low-income countries. Secondary prevention through screening faces challenges in public engagement, often leading to late-stage diagnoses. Recent advancements in novel anti-HPV drugs offer expanded opportunities for cervical cancer management.
Aim
This review examines emerging anti-HPV therapeutics to provide insights into innovative strategies for cervical cancer prevention and treatment.
Methods
We conducted a systematic analysis of published studies investigating anti-HPV agents, focusing on their molecular mechanisms and clinical efficacy in cervical cancer prevention.
Results & Conclusions
Multiple promising anti-HPV agents have been identified, including 3-hydroxyphthalic anhydride-modified bovine β-lactoglobulin (3HP-β-LG), carrageenan, defensins, and 25-hydroxycholesterol (25HC). These compounds exert antiviral effects through distinct mechanisms: 3HP-β-LG competitively inhibits viral attachment, carrageenan blocks HPV entry via heparan sulfate mimicry, defensins inhibit the dissociation of viral capsid, and 25HC activates cholesterol-mediated antiviral pathways. They have demonstrated strong inhibitory effects on HPV infection, making them novel therapeutic candidates for the prevention and treatment of cervical cancer.
期刊介绍：
Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas:
Clinical Cancer Research
Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations
Cancer Biology:
Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery.
Cancer Prevention:
Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach.
Bioinformatics:
Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers.
Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
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