Frauke Beyer, Ami Tsuchida, Aicha Soumaré, Hema Sekhar Reddy Rajula, Aniket Mishra, Fabrice Crivello, Cécile Proust-Lima, Markus Loeffler, Christophe Tzourio, Philippe Amouyel, Arno Villringer, Markus Scholz, Hélène Jacqmin-Gadda, Marc Joliot, A. Veronica Witte, Carole Dufouil, Stéphanie Debette
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We explored clinical and genetic correlates of agnostically derived spatial WMH patterns in two longitudinal population-based cohorts (Three-City Study [3C]-Dijon, LIFE-Adult).</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We derived seven WMH spatial patterns using Bullseye segmentation in 2878 individuals aged 65+ and explored their associations with vascular and genetic risk factors, cognitive performance, dementia and stroke incidence.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>WMHs in the frontoparietal and anterior periventricular region were associated with blood pressure traits, WMH genetic risk score (GRS), baseline and decline in general cognitive performance, incident all-cause dementia, and ischemic stroke. Juxtacortical-deep occipital WMHs were not associated with vascular risk factors and WMH GRS, but with incident all-cause dementia and intracerebral hemorrhage.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Accounting for WMH spatial distribution is key to deciphering mechanisms underlying cSVD subtypes, an essential step towards personalized therapeutic approaches.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>We studied spatial patterns of WMHs in 2878 participants.</li>\n \n <li>Blood pressure was associated with frontoparietal and anterior PV WMHs.</li>\n \n <li>Anterior PV WMHs predicted dementia and stroke risk.</li>\n \n <li>Juxtacortical-deep occipital WMH burden was not associated with blood pressure or WMH genetic risk.</li>\n \n <li>Juxtacortical-deep occipital WMH burden predicted dementia and intracerebral hemorrhage.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70053","citationCount":"0","resultStr":"{\"title\":\"White matter hyperintensity spatial patterns: Risk factors and clinical correlates\",\"authors\":\"Frauke Beyer, Ami Tsuchida, Aicha Soumaré, Hema Sekhar Reddy Rajula, Aniket Mishra, Fabrice Crivello, Cécile Proust-Lima, Markus Loeffler, Christophe Tzourio, Philippe Amouyel, Arno Villringer, Markus Scholz, Hélène Jacqmin-Gadda, Marc Joliot, A. 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White matter hyperintensity spatial patterns: Risk factors and clinical correlates
INTRODUCTION
White matter hyperintensities (WMHs), a major cerebral small vessel disease (cSVD) marker, may arise from different pathologies depending on their location. We explored clinical and genetic correlates of agnostically derived spatial WMH patterns in two longitudinal population-based cohorts (Three-City Study [3C]-Dijon, LIFE-Adult).
METHODS
We derived seven WMH spatial patterns using Bullseye segmentation in 2878 individuals aged 65+ and explored their associations with vascular and genetic risk factors, cognitive performance, dementia and stroke incidence.
RESULTS
WMHs in the frontoparietal and anterior periventricular region were associated with blood pressure traits, WMH genetic risk score (GRS), baseline and decline in general cognitive performance, incident all-cause dementia, and ischemic stroke. Juxtacortical-deep occipital WMHs were not associated with vascular risk factors and WMH GRS, but with incident all-cause dementia and intracerebral hemorrhage.
DISCUSSION
Accounting for WMH spatial distribution is key to deciphering mechanisms underlying cSVD subtypes, an essential step towards personalized therapeutic approaches.
Highlights
We studied spatial patterns of WMHs in 2878 participants.
Blood pressure was associated with frontoparietal and anterior PV WMHs.
Anterior PV WMHs predicted dementia and stroke risk.
Juxtacortical-deep occipital WMH burden was not associated with blood pressure or WMH genetic risk.
Juxtacortical-deep occipital WMH burden predicted dementia and intracerebral hemorrhage.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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