用于绘制肠绞窄患者组织氧饱和度分布图的双模式超声波/照相声断层成像技术

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2025-04-01 DOI:10.1016/j.pacs.2025.100721

Jie Zhou , Mengchuan Ou , Bo Yuan , Binzi Yan , Xichuan Wang , Shuaiqi Qiao , Yijie Huang , Lian Feng , Lin Huang , Yan Luo

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Dual-modality ultrasound/photoacoustic tomography for mapping tissue oxygen saturation distribution in intestinal strangulation

The strangulation of intestinal obstruction (IO) presents challenges in the assessment of disease progression and surgical decision-making. Intraoperatively, an accurate evaluation of the status of the IO is critical for determining the extent of surgical resection. Dual-modality ultrasound/photoacoustic tomography (US/PAT) imaging has the potential to provide spatially resolved tissue oxygen saturation (SO₂), serving as a valuable marker for IO diagnosis. In this study, US/PAT was utilized for imaging rat models of IO, with the data used for reconstruction, statistical analysis, and distribution evaluation. Results showed that SO₂ decreased with increasing strangulation severity. Notably, the kurtosis and skewness of the SO₂ distribution outperformed SO₂ itself in diagnosis, as they more effectively capture the heterogeneity of SO₂ distribution. Kurtosis reflects distribution concentration, while skewness measures asymmetry, both achieving areas under the receiver operating characteristic curve (AUROC) of 0.969. In conclusion, US/PAT offers a rapid and convenient method for assessing strangulation in IO.

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.