IL-16多态性与膝骨关节炎易感性相关数据的全面分析：荟萃分析

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-04-07 DOI:10.1016/j.cyto.2025.156929

Amirhossein Omidi , Mohammad Bahrami , Seyed Alireza Dastgheib , Ahmadreza Golshan-Tafti , Ali Masoudi , Amirmasoud Shiri , Maryam Aghasipour , Amirhossein Shahbazi , Kazem Aghili , Hossein Neamatzadeh

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引用次数: 0

摘要

膝关节骨性关节炎（KOA）是一种受遗传和环境因素影响的多因素疾病。研究已经探索了IL-16基因多态性与KOA风险之间的关系，但研究结果尚无定论。本荟萃分析旨在评估IL-16多态性与KOA风险之间的关系。方法系统检索PubMed、Web of Science、EMBASE、SciELO、CNKI等数据库中截至2024年6月1日已发表的研究。两名独立的研究人员使用与“膝关节骨关节炎”和“白细胞介素16”相关的关键词，识别了英语、葡萄牙语和中文的同行评议文章。还手工审查了相关的参考文献，以便进行更多的研究。计算合并优势比（ORs）和95%置信区间（ci）来评估关联强度。此外，还评估了次要等位基因频率（MAFs）、Hardy-Weinberg平衡（HWE）数据、异质性、发表偏倚和Newcastle-Ottawa评分（NOS）。结果本分析纳入15项病例对照研究，包括1747例KOA患者和1627例健康对照。在这些研究中，5项研究了rs11556218（584例，542例对照）、rs4778889（583例，543例对照）和rs4072111（580例，542例对照）的遗传变异。研究结果表明，IL-16变体rs11556218和rs4072111可能对KOA的发展提供保护，而rs4778889变体与KOA易感性之间不存在联系。IL-16多态性的可变性，特别是在亚洲和中国人群中，表明了与KOA风险的不同遗传关联。在敏感性分析和没有显著发表偏倚的支持下，强有力的结果强调了研究方法对这些多态性与KOA风险之间关系的影响。结论rs11556218、rs4778889和rs4072111三个多态性与KOA存在不同程度的相关性。Rs11556218和rs4072111在非亚洲人群中具有保护作用，而rs4778889在队列中没有显着关联。值得注意的是，rs11556218和rs4072111与亚洲和中国人群的KOA易感性无关，这表明遗传对KOA的影响存在种族差异。

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A thorough analysis of data on the correlation between IL-16 polymorphisms and the susceptibility to knee osteoarthritis: A meta-analysis

Background

Knee osteoarthritis (KOA) is a multifactorial condition affected by genetic and environmental factors. Studies have explored the relationship between IL-16 genetic polymorphisms and KOA risk, but findings have been inconclusive. This meta-analysis seeks to assess the association between IL-16 polymorphisms and KOA risk.

Methods

A systematic literature search was conducted in several databases, including PubMed, Web of Science, EMBASE, SciELO, and CNKI, for studies published until June 1, 2024. Two independent researchers identified peer-reviewed articles in English, Portuguese, and Chinese using keywords related to “Knee Osteoarthritis” and “Interleukin 16.” Relevant references were also manually reviewed for additional studies. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to assess the association strength. Additionally, minor allele frequencies (MAFs), Hardy-Weinberg equilibrium (HWE) data, heterogeneity, publication bias, and Newcastle-Ottawa scores (NOS) were evaluated.

Results

This analysis included 15 case-control studies, encompassing 1747 individuals with KOA and 1627 healthy controls. Within these studies, five investigated the genetic variations rs11556218 (584 cases, 542 controls), rs4778889 (583 cases, 543 controls), and rs4072111 (580 cases, 542 controls). The findings suggest that the IL-16 variants rs11556218 and rs4072111 may offer protection against KOA development, while no link exists between the rs4778889 variant and KOA susceptibility. The variability in IL-16 polymorphisms, particularly in Asian and Chinese populations, indicates different genetic associations with KOA risk. Strong results, supported by sensitivity analyses and the absence of significant publication bias, emphasize the influence of study methods on the relationship between these polymorphisms and KOA risk.

Conclusions

The analysis of three polymorphisms—rs11556218, rs4778889, and rs4072111—shows varying associations with KOA. Rs11556218 and rs4072111 offer protective effects in non-Asian populations, while rs4778889 shows no significant association across cohorts. Notably, rs11556218 and rs4072111 do not correlate with KOA susceptibility in Asian and Chinese populations, suggesting ethnic differences in genetic influences on KOA.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.