突触核蛋白病的新生物学疾病标准在系统突触核蛋白抽样研究队列中的应用

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-04-06 DOI:10.1038/s41531-025-00919-y

L. M. Chahine, M. C. Brumm, A. R. Nair, S. Mosovsky, N. K. Polinski, T. G. Beach, B. Mollenhauer, C. H. Adler

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引用次数: 0

摘要

我们将生物学标准和NSD-ISS应用于突触核蛋白采样研究，这是一种自临床诊断以来持续时间范围的PD样本。93%的可评估参与者符合生物学标准。大多数为NSD-ISS 3期或以下，包括40%的晚期PD组。对服药患者的分期进行解释是具有挑战性的。生物学标准和临床生物标志物分期是向前迈出的重要一步，但目前迫切需要不受药物影响的疾病进展的定量生物标志物。

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Application of new biologic disease criteria for synucleinopathies to the systemic synuclein sampling study cohort

We applied biologic criteria and NSD-ISS to Synuclein Sampling Study, a PD sample with range of durations since clinical diagnosis. 93% of evaluable participants met biologic criteria. The majority were NSD-ISS stage3 or less, including >40% of the advanced PD group. Interpretation of staging in medicated patients is challenging. Biologic criteria and clinico-biomarker staging are important steps forward, but quantitative biomarkers of disease progression, not influenced by medications, are critically needed.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.