A Contrast-Enhanced Null Subtraction Imaging Method using Dynamic DC Bias in Ultrafast Ultrasound imaging.

Enhancing the resolution and contrast of ultrafast ultrasound imaging is imperative for the accuracy of clinical diagnostics. Null subtraction imaging (NSI) is a nonlinear beamforming technique capable of significantly enhancing lateral resolution. However, it suffers from issues of low-quality speckle pattern and poor contrast performance. To address this issue, we propose a novel contrast-enhanced NSI method that utilizes dynamic DC bias. Innovatively, we construct the dynamic DC bias using a generalized coherence factor (GCF) and a sigmoid transformation function that adapts the DC value based on the signal characteristics of different imaging regions. Furthermore, a normalization scheme is proposed to optimize the beamforming output, ensuring uniform pixel intensity throughout the final image. Simulation, phantom, and in vivo data are utilized for ultrasound beamforming to evaluate the performance of the proposed method. Quantitative results show that the proposed method significantly enhances the contrast ratio (CR) by 197%, the contrast-to-noise ratio (CNR) by 341%, the speckle signal-to-noise ratio (sSNR) by 302%, and the generalized contrast-to-noise ratio (gCNR) by 106% compared to the original NSI (in phantom). Point target imaging results indicate that the proposed method achieves a main lobe width slightly wider than the original NSI method, but much narrower than those of DAS and GCF. These findings confirm that the proposed method significantly enhances imaging contrast while preserving high resolution, which is of great significance for the further clinical application of ultrafast ultrasound imaging.